N3911

NBI 27914

≥98% (HPLC)

• Synonym(e): 5-Chloro-4-(N-(cyclopropyl)methyl-N-propylamino)-2-methyl-6-(2,4,6-trichlorophenyl)aminopyridine
• Empirische Formel (Hill-System): C₁₈H₂₀Cl₄N₄
• CAS-Nummer: 184241-44-9
• Molekulargewicht: 434.19
• MDL-Nummer: MFCD05662281
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278425
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: white
• Löslichkeit: DMSO: >20 mg/mL at 60 °C; H₂O: insoluble
• Lagertemp.: 2-8°C
• SMILES String: CCCN(CC1CC1)c2nc(C)nc(Nc3c(Cl)cc(Cl)cc3Cl)c2Cl
• InChI: 1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
• InChIKey: KNADXBVKFAUMCR-UHFFFAOYSA-N
• Angaben zum Gen: human ... CRHR1(1394)

Beschreibung

Anwendung

NBI 27914 has been used as acorticotropin-releasing hormone receptor (CRHR1) antagonist:

• to study its effects on steroidogenic gene expression in GD15 mouse testis
• to study its effects on amyloid β production
• to study its effects on neurogenic activity of neural stem cells in the adult hippocampus

Biochem./physiol. Wirkung

NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves