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N3415

Sigma-Aldrich

Nifurtimox

≥98% (HPLC)

Synonym(e):

(RS)-3-methyl-N-[(1E)-(5-nitro-2-furyl)methylene]thiomorpholin-4-amine 1,1-dioxide, (±)-Nifurtimox, 3-Methyl-4-(5′-nitrofurylidene-amino)-tetrahydro-4H-1,4-thiazine-1,1-dioxide; 4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine 1,1-dioxide, BAY 2502, Thiomorpholine, 3-methyl-4-((5-nitrofurfurylidene)amino)-,1,1-dioxide

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About This Item

Empirische Formel (Hill-System):
C10H13N3O5S
CAS-Nummer:
23256-30-6
Molekulargewicht:
287.29
EG-Nummer:
245-531-0
MDL-Nummer:
MFCD00869254
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329818609
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

yellow to orange

Löslichkeit

DMSO: ≥13 mg/mL

Ersteller

Bayer

Lagertemp.

room temp

SMILES String

CC1CS(=O)(=O)CCN1\N=C\c2ccc(o2)[N+]([O-])=O

InChI

1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3/b11-6+

InChIKey

ARFHIAQFJWUCFH-IZZDOVSWSA-N

Allgemeine Beschreibung

Nifurtimox acts as a hypoxia-activated cytotoxin, which specifically kills clonogenic tumor cells under hypoxic conditions. It is used to treat Chagas disease and African trypanosomiasis. Nifurtimox inhibits neuroblastoma and medulloblastoma cell growth.

Anwendung

Nifurtimox has been used in drug treatment in culture media.

Biochem./physiol. Wirkung

Nifurtimox is a nitrofurane derivative used to treat diseases caused by trypanosomes. Nifurtimox was discovered empirically and its mechanism of action is unclear. It is believed that nifurtimox exerts its biological activity through the bioreduction of the nitro-group to a nitro-anion radical which undergoes redox-cycling with molecular oxygen.

Leistungsmerkmale und Vorteile

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Tolerance and safety of nifurtimox in patients with chronic chagas disease
Jackson Y, et al.
Clinical Infectious Diseases, 51(10), e69-e75 (2010)
Antitrypanosomal therapy for chronic Chagas' disease.
Caryn Bern
The New England journal of medicine, 364(26), 2527-2534 (2011-07-01)
Anis Rassi et al.
Infectious disease clinics of North America, 26(2), 275-291 (2012-05-29)
Chagas disease, also known as American trypanosomiasis, is a chronic infection caused by Trypanosoma cruzi, a protozoan parasite. It is transmitted to human beings mainly through the feces of infected triatomine bugs. The disease affects an estimated 8 to 10
Yves Jackson et al.
BMC infectious diseases, 13, 85-85 (2013-02-15)
With declining vectorial transmission, Chagas disease predominantly affects adults nowadays. The efficacy of nifurtimox in the chronic phase in adult patients is poorly known, particularly in regions where there is no risk of reinfection. Recommendations for treatment outcome assessment rely
The anti-protozoan drug nifurtimox preferentially inhibits clonogenic tumor cells under hypoxic conditions
Li Q, et al.
American Journal of Cancer Research, 7(5), 1084-1084 (2017)
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