N3040

Necrostatin-7

≥98% (HPLC), powder

• Synonym(e): 5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone, Nec-7
• Empirische Formel (Hill-System): C₁₆H₁₀FN₅OS₂
• CAS-Nummer: 351062-08-3
• Molekulargewicht: 371.41
• MDL-Nummer: MFCD02334728
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329818601

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: yellow to tan
• Löslichkeit: DMSO: >10 mg/mL (with warming)
• Lagertemp.: 2-8°C
• SMILES String: Fc1ccc(cc1)-c2n[nH]cc2C=C3SC(=N)N(C3=O)c4nccs4
• InChI: 1S/C16H10FN5OS2/c17-11-3-1-9(2-4-11)13-10(8-20-21-13)7-12-14(23)22(15(18)25-12)16-19-5-6-24-16/h1-8,18H,(H,20,21)
• InChIKey: SMJGLNVGTJLIRV-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Necrostatin-7 (Nec-7) is a potent inhibitor of necroptosis, a regulated caspase-independent necrotic cell death pathway, distinct from apoptosis. Nec-7 has a different profile from the other necrostatins as it does not inhibit RIP1 kinase, suggesting the possibility that it may target an additional as yet unknown regulatory molecule in the pathway.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable