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Merck

N0761

Sigma-Aldrich

Nicotinsäure

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%

Synonym(e):

3-Picolinsäure, Niacin, Pellagra Präventivfaktor, Pyridin-3-carbonsäure, Vitamin B3

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About This Item

Empirische Formel (Hill-System):
C6H5NO2
CAS-Nummer:
Molekulargewicht:
123.11
Beilstein:
109591
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352207
PubChem Substanz-ID:
NACRES:
NA.71

Produktlinie

BioReagent

Assay

≥98%

Form

powder

Mol-Gew.

Mw 123.11 g/mol

Methode(n)

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

Farbe

white to off-white

pH-Wert

3.4 (20 °C, 10 g/L)

mp (Schmelzpunkt)

236-239 °C (lit.)

Löslichkeit

1 M NaOH: soluble 50 mg/mL, clear, colorless to very faintly yellow

Dichte

1.473 g/cm3 at 25 °C

Anwendung(en)

agriculture

SMILES String

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

InChIKey

PVNIIMVLHYAWGP-UHFFFAOYSA-N

Angaben zum Gen

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

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Piktogramme

Exclamation mark

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Eye Irrit. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

379.4 °F - closed cup

Flammpunkt (°C)

193 °C - closed cup

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves


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Beat Müller et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 20(2), 181-195 (2003-10-11)
A novel methodology for establishing a pharmacological dose-effect relationship of methyl nicotinate, hexyl nicotinate and nicotinic acid acting as peripheral vasodilators in the skin following topical application is investigated. This methodology involves the estimation of the unbound drug concentration in
Paul M Lavigne et al.
Journal of the American College of Cardiology, 61(4), 440-446 (2012-12-26)
This study sought to assess the efficacy of niacin for reducing cardiovascular disease (CVD) events, as indicated by the aggregate body of clinical trial evidence including data from the recently published AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High
Koon K Teo et al.
Stroke, 44(10), 2688-2693 (2013-07-25)
In Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcomes (AIM-HIGH) trial, addition of extended-release niacin (ERN) to simvastatin in participants with established cardiovascular disease, low high-density lipoprotein cholesterol, and high triglycerides had no incremental
John R Guyton et al.
Journal of the American College of Cardiology, 62(17), 1580-1584 (2013-08-07)
This study sought to examine the relationship between niacin treatment, lipoproteins, and cardiovascular (CV) outcomes in this secondary analysis of the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes) trial. During a
Martina Lukasova et al.
Trends in pharmacological sciences, 32(12), 700-707 (2011-09-29)
Nicotinic acid (niacin) has been used for decades to prevent and treat atherosclerosis. The well-documented antiatherogenic activity is believed to result from its antidyslipidemic effects, which are accompanied by unwanted effects, especially a flush. There has been renewed interest in

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