M7317

Monoclonal Anti-MDR3 P-Glycoprotein antibody produced in mouse

250 μg/mL, clone P₃II-26, tissue culture supernatant

• Synonym(e): Anti-ABC21, Anti-GBD1, Anti-ICP3, Anti-MDR2, Anti-MDR2/3, Anti-MDR3, Anti-PFIC-3, Anti-PGY3
• MDL-Nummer: MFCD03791722
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: tissue culture supernatant
• Antikörper-Produkttyp: primary antibodies
• Klon: P₃II-26, monoclonal
• Speziesreaktivität: human
• Konzentration: 250 μg/mL
• Methode(n): immunocytochemistry: 1:20-1:50 using acetone-fixed cytospin preparations; immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable (not suitable for human tissues); immunohistochemistry (frozen sections): 1:20 using acetone-fixed sections; western blot: suitable
• Isotyp: IgG2b
• UniProt-Hinterlegungsnummer: P21439
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ABCB11(8647) , ABCB4(5244)

Beschreibung

Allgemeine Beschreibung

Multidrug resistance protein 3 (MDR3) is also known as ATP binding cassette subfamily B member 4. It is expressed in hepatocytes and made up of 1279 amino acids. The gene encoding it is localized on human chromosome 7q21.12 and consists of 27 exons.

Spezifität

Reacts with an internal epitope of MDR3. Does not cross-react with human MDR1 P-gp.

Immunogen

MDR3 P-gp (amino acids 629-692) GST fusion protein.

Biochem./physiol. Wirkung

Multidrug resistance protein 3 (MDR3) acts as an ATP-dependent exporter and transfers phospholipids, particularly phosphatidylcholine (PC), into bile. Dysfunctioning of MDR3 leads to excess of bile salts in primary bile and further leads to liver diseases.

Physikalische Form

Supplied in serum-free medium containing 0.7% bovine serum albumin and 0.1% sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable