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M6680

Sigma-Aldrich

Se-(Methyl)selenocysteine hydrochloride

≥95% (TLC)

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About This Item

Empirische Formel (Hill-System):
C4H9NO2Se · HCl
CAS-Nummer:
863394-07-4
Molekulargewicht:
218.54
MDL-Nummer:
MFCD03412450
UNSPSC-Code:
12352209
PubChem Substanz-ID:
24278564
NACRES:
NA.32

Assay

≥95% (TLC)

Lagertemp.

−20°C

SMILES String

Cl.C[Se]C[C@H](N)C(O)=O

InChI

1S/C4H9NO2Se.ClH/c1-8-2-3(5)4(6)7;/h3H,2,5H2,1H3,(H,6,7);1H/t3-;/m0./s1

InChIKey

JMPVTFHGWJDSDV-DFWYDOINSA-N

Allgemeine Beschreibung

Selenium (Se)-(Methyl) selenocysteine (MeSeCys) is a methylated product of selenocysteine, this reaction is catalyzed by selenocysteine methyltransferase (SMT) in Astragalus bisulcatus.

Anwendung

Se-(Methyl) selenocysteine hydrochloride has been used as a standard in fluorescence-XANES (X-ray absorption near-edge spectroscopy) imaging.

Biochem./physiol. Wirkung

Selenium (Se)-(Methyl) selenocysteine functions as a potent chemotherapeutic agent for human breast cancer. Enhanced production of methlylselenol from L-Se-methylselenocysteine in vivo alters redox status of cells and oxidatively triggers cellular apoptosis. It is implicated in inhibition of mammary tumor formation in rats.
Se-(Methyl)selenocysteine is a chemopreventive agent that blocks cell cycle progression and proliferation of premalignant mammary lesions and induces apoptosis of cancer cell lines in culture.

Anwendung

Produkt-Nr.
Beschreibung
Preisangaben

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Lagerklassenschlüssel

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Natriumselenat BioXtra

Sigma-Aldrich

S8295

Natriumselenat

DL-Methionin European Pharmacopoeia (EP) Reference Standard

M0950000

DL-Methionin

Dimethylselenid ≥99.0% (GC)

Sigma-Aldrich

41572

Dimethylselenid

Selenharnstoff 98%

Sigma-Aldrich

230499

Selenharnstoff

Natriumselenit 99%

Sigma-Aldrich

214485

Natriumselenit

Dimethyldiselenide and methylseleninic acid generate superoxide in an in vitro chemiluminescence assay in the presence of glutathione: implications for the anticarcinogenic activity of L-selenomethionine and L-Se-methylselenocysteine.
Spallholz JE
Nutrition and Cancer, 40(1), 34-41 (2001)
Synchrotron-based X-ray absorption near-edge spectroscopy imaging for laterally resolved speciation of selenium in fresh roots and leaves of wheat and rice.
Wang P
Journal of Experimental Botany, 66(15), 4795-4806 (2015)
Junkun Ma et al.
Biological trace element research, 191(1), 159-166 (2018-12-14)
Mastitis is one of the most important diseases affecting the dairy industry in the world, and it also poses a great threat to human food safety. In this study, we explored whether selenium can inhibit the activation of the NALP3
N V Dolgova et al.
Metallomics : integrated biometal science, 8(3), 305-312 (2016-01-20)
Selenium is an essential micronutrient for many organisms, and in vertebrates has a variety of roles associated with protection from reactive oxygen species. Over the past two decades there have been conflicting reports upon human health benefits and detriments arising
Se-methylselenocysteine: a new compound for chemoprevention of breast cancer.
Medina D
Nutrition and Cancer, 40(1), 12-17 (2001)
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Artikel

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Chromatograms

application for HPLC

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