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M5693

MEDICA 16

Name: MEDICA 16
Brand: SIGMA

powder, ≥97% (HPLC)

Synonym(e):

3,3,14,14-Tetramethylhexadecanedioic acid

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About This Item

Empirische Formel (Hill-System):

C₂₀H₃₈O₄

CAS-Nummer:

87272-20-6

Molekulargewicht:

342.51

MDL-Nummer:

MFCD00797684

UNSPSC-Code:

12352200

PubChem Substanz-ID:

24724539

NACRES:

NA.77

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Sigma-Aldrich

D5628

Digitonin

Assay

≥97% (HPLC)

Form

powder

Farbe

white to beige

mp (Schmelzpunkt)

154-159 °C

Löslichkeit

DMSO: 10 mg/mL, clear

Versandbedingung

wet ice

Lagertemp.

−20°C

SMILES String

CC(C)(CCCCCCCCCCC(C)(C)CC(O)=O)CC(O)=O

InChI

1S/C20H38O4/c1-19(2,15-17(21)22)13-11-9-7-5-6-8-10-12-14-20(3,4)16-18(23)24/h5-16H2,1-4H3,(H,21,22)(H,23,24)

InChIKey

HYSMCRNFENOHJH-UHFFFAOYSA-N

Biochem./physiol. Wirkung

MEDICA 16 is an ATP-citrate lyase inhibitor and potent triacylglycerol-lowering agent. The product is hypolipidemic, antidiabetic, and shows reduced adiposity.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Adipose tissue sensitization to insulin induced by troglitazone and MEDICA 16 in obese Zucker rats in vivo.

Bella Kalderon et al.

American journal of physiology. Endocrinology and metabolism, 284(4), E795-E803 (2002-12-19)

The putative role played by insulin sensitizers in modulating adipose tissue lipolysis in the fasting state was evaluated in obese conscious Zucker rats treated with troglitazone or beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) and compared with nontreated lean and obese animals. The

Mitochondrial protonophoric activity induced by a thyromimetic fatty acid analogue.

O Hermesh et al.

Biochimica et biophysica acta, 1457(3), 166-174 (2000-04-25)

Calcium-dependent uncoupling of liver mitochondrial oxidative phosphorylation by a non-metabolizable long chain fatty acyl analogue was compared with uncoupling induced by in vivo thyroid hormone treatment. beta,beta'-Methyl-substituted hexadecane alpha, omega-dioic acid (Medica 16) is reported here to induce a saturable

Inhibition of rat liver acetyl-CoA carboxylase by beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16).

G Rose-Kahn et al.

Biochimica et biophysica acta, 1042(2), 259-264 (1990-02-06)

Rat liver acetyl-CoA carboxylase activity was inhibited by the free as well as the CoA monothioester of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) (Bar-Tana, J., Rose-Kahn, G. and Srebnik, M. (1985) J. Biol. Chem. 260, 8404-8410 (1985). (1) The CoA

Suppression of hepatocyte nuclear factor-4alpha by acyl-CoA thioesters of hypolipidemic peroxisome proliferators.

R Hertz et al.

Biochemical pharmacology, 61(9), 1057-1062 (2001-04-13)

Hepatocyte nuclear factor-4alpha (HNF-4alpha) modulates the expression of liver-specific genes that control the production (e.g. apolipoprotein [apo] A-I and apo B) and clearance (e.g. apo C-III) of plasma lipoproteins. We reported that the CoA thioesters of amphipathic carboxylic hypolipidemic drugs

Effect of beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16) on laying hen performance and egg yolk lipid composition.

R G Elkin et al.

British poultry science, 33(3), 677-681 (1992-07-01)

1. beta, beta'-tetramethyl-substituted hexadecanedioic acid (MEDICA 16), an inhibitor of hepatic cholesterogenesis and lipogenesis in rats, was orally administered to 24-week-old White Leghorn hens for a period of 16 d. Hens were fed maize-soya-bean meal diets containing 0, 1.5, or

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