M5273

Monensin Natriumsalz

90-95% (TLC)

• Synonym(e): Monensin A Natriumsalz
• Empirische Formel (Hill-System): C₃₆H₆₁NaO₁₁
• CAS-Nummer: 22373-78-0
• Molekulargewicht: 692.85
• Beilstein: 4122200
• EG-Nummer: 244-941-7
• MDL-Nummer: MFCD00077826
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24896992
• NACRES: NA.77

Eigenschaften

• Assay: 90-95% (TLC)
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria; fungi; parasites; viruses
• Wirkungsweise: cell membrane | interferes
• Lagertemp.: 2-8°C
• SMILES String: [H][C@]1([C@@]2(CC)O[C@]([C@@]3(C)OC4(C[C@H](O)[C@@H](C)[C@@]([H])([C@@H](C)[C@@H](OC)[C@@H](C([O-])=O)C)O4)CC3)([H])CC2)[C@@H](C)C[C@]([H])([C@@]5([H])O[C@@](O)(CO)[C@H](C)C[C@@H]5C)O1.[Na+]
• InChI: 1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35?,36-;/m0./s1
• InChIKey: XOIQMTLWECTKJL-BEMBKCOJSA-M

Beschreibung

Allgemeine Beschreibung

Chemical structure: polyether

Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis in poultry production.

Anwendung

Monensin sodium salt has been used:

• for the intracellular staining of cytokines
• to study its effects on the regulation of nuclear factor-κ B (NF-κB ) activation
• as a positive control to study its effects on in vitro rumen fermentation

Biochem./physiol. Wirkung

Na⁺ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

Angaben zur Herstellung

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08,GHS09
• Signalwort: Danger
• H-Sätze: H300,H319,H373,H411
• P-Sätze: P260 - P264 - P273 - P301 + P310 - P305 + P351 + P338 - P314
• Gefahreneinstufungen: Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2
• Zielorgane: Heart,muscle
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges