M4565
Matrix Metalloproteinase-7 human
~0.1 mg/mL, recombinant, expressed in E. coli, buffered aqueous solution
Synonym(e):
MMP-7, Matrilysin-1
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About This Item
Empfohlene Produkte
Rekombinant
expressed in E. coli
Qualitätsniveau
Form
buffered aqueous solution
Spezifische Aktivität
5,000 units/mg protein
Mol-Gew.
20 kDa
Konzentration
~0.1 mg/mL
UniProt-Hinterlegungsnummer
Relevante Krankheit(en)
cancer
Versandbedingung
dry ice
Lagertemp.
−70°C
Angaben zum Gen
human ... MMP7(4316)
Allgemeine Beschreibung
Matrix metalloproteinase-7 (MMP7) also referred to as matrilysin is encoded by the gene mapped to human chromosome 11q21-q22. MMP7 is a smallest member of MMP enzyme family and is highly expressed in cancer cells. MMP7 is exclusively released by epithelial cells.
Anwendung
Matrix metalloproteinase-7 (MMP7) human has been used in in silico analysis of MMP-7 proteolysis of perlecan.
Biochem./physiol. Wirkung
Matrix metalloproteinase-7 (MMP-7) catalyzes the cleavage of extracellular matrix (ECM) proteins such as proteoglycans, fibronectin, entactin, laminin, collagen III/ IV/ V/ IX/ X/ XI, type I/ II/ IV/ V gelatins, and elastin. Matrix metalloproteinase-7 facilitates initial stages of tumor progression. Activated MMP7 plays a vital role in human colorectal cancer (CRC) liver metastases. Overexpression of MMP7 is observed in various human cancers, such as breast, lung, prostate, esophagus, stomach, endometrium, and ovarian carcinomas, as well as esophageal squamous cell carcinomas. Increased expression of MMP7 is also associated with pathogenesis of demyelinating multiple sclerosis (MS) lesions. Both in silico and in vitro studies show that MMP7 degrades glycosylated and basement membrane bound perlecan and plays a vital role in prostate cancer cell invasion.
Physikalische Form
Solution in 10 mM HEPES, 5 mM CaCl2, 150 mM NaCl
Hinweis zur Analyse
One unit of enzyme activity is defined as the digestion of 1 μg of azocoll/min. at pH 7.5 and 37 °C.
Lagerklassenschlüssel
10 - Combustible liquids
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior.
Grindel BJ, et.al.
Matrix Biology, 36, 64-76 (2014)
Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions.
Cossins JA
Acta Neuropathologica, 94(6), 590-598 (1997)
Matrilysin.
Wilson, C.L. et al.
Matrix Metalloproteinases, 149-149 (1998)
Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-->q22.
Knox JD
Cytogenetics and Cell Genetics, 72(2-3), 179-182 (1996)
Matrix metalloproteinase-7 expression in colorectal cancer liver metastases: evidence for involvement of MMP-7 activation in human cancer metastases.
Zeng ZS
Clinical Cancer Research, 8(1), 144-148 (2002)
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