M2383

α-(Methylamino)-isobuttersäure

≥97% (titration)

• Synonym(e): 2,N-Dimethyl-alanin, 2-(Methylamino)-2-methyl-propionsäure
• Lineare Formel: CH₃NHC(CH₃)₂COOH
• CAS-Nummer: 2566-34-9
• Molekulargewicht: 117.15
• Beilstein: 1746984
• EG-Nummer: 219-898-2
• MDL-Nummer: MFCD00004191
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 24896726
• NACRES: NA.26

Eigenschaften

• Assay: ≥97% (titration)
• Form: powder
• Methode(n): ligand binding assay: suitable
• Farbe: white
• mp (Schmelzpunkt): >300 °C (lit.)
• Lagertemp.: −20°C
• SMILES String: CNC(C)(C)C(O)=O
• InChI: 1S/C5H11NO2/c1-5(2,6-3)4(7)8/h6H,1-3H3,(H,7,8)
• InChIKey: DLAMVQGYEVKIRE-UHFFFAOYSA-N

Beschreibung

Anwendung

α-(Methylamino)isobutyric acid (MeAIB) has been used:

• as a system A transport system inhibitor to perform inhibition experiments
• as a system A transport system inhibitor to study its effect on the generation of epileptiform field potentials (EFPs) in the acutely disinhibited cortical slices
• as an N-acetyltransferase (SNAT) inhibitor in Hank′s balanced salt solution (HBSS) to study its influence on the uptake of ¹⁴C-cysteine/ radioactive-labeled cysteine

Biochem./physiol. Wirkung

α-(Methylamino)isobutyric acid (MeAIB), a competitive inhibitor of the neutral amino acid transport A system, is an N-methylated substrate. It is capable of decreasing the amplitude of the miniature excitatory postsynaptic current (mEPSC) in hippocampus neurons developing on top of astrocytes. MeAIB can block the alanine-proline (AP) pathway.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H319
• P-Sätze: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves