M2199

PMEG hydrate

≥98% (HPLC)

• Synonym(e): 9-[2-(Phosphonomethoxy)ethyl]guanine hydrate
• Empirische Formel (Hill-System): C₈H₁₂N₅O₅P · xH₂O
• CAS-Nummer: 1255517-79-3
• Molekulargewicht: 289.19 (anhydrous basis)
• MDL-Nummer: MFCD19443863
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329817932
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to off-white
• Löslichkeit: DMSO: ≥5 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: O.NC1=Nc2c(ncn2CCOCP(O)(O)=O)C(=O)N1
• InChI: 1S/C8H12N5O5P.H2O/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-18-4-19(15,16)17;/h3H,1-2,4H2,(H2,15,16,17)(H3,9,11,12,14);1H2
• InChIKey: BDVQXHFCXJXVND-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

The acyclic nucleotide 9-(2-phosphonylmethoxyethyl)guanine (PMEG) forms an active phosphorylated metabolite, PMEG diphosphate (PMEGpp), in cells and causes cytotoxicity in dividing cells due to potent inhibition of the nuclear DNA polymerases resulting in inhibition of DNA synthesis and/or DNA repair.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 2 Oral
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3