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L9536

Sigma-Aldrich

Anti-Leptin Receptor antibody produced in goat

affinity isolated antibody, lyophilized powder

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About This Item

MDL-Nummer:
MFCD02096819
UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

goat

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

affinity isolated antibody

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

lyophilized powder

Speziesreaktivität

mouse

Methode(n)

flow cytometry: suitable
immunohistochemistry (frozen sections): suitable
western blot: suitable

UniProt-Hinterlegungsnummer

P48356

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

mouse ... Lepr(16847)

Immunogen

recombinant mouse leptin receptor expressed in NS0 cells.

Biochem./physiol. Wirkung

Leptin is a hormone secreted by adipocytes and regulates energy homeostasis, inflammation and neuroendocrine processes, synaptic formation and memory condensation. The physiological effects of leptin are mediated by leptin receptors, ObR and LepR. Leptin is the key regulator of obesity and acts directly on neuronal networks to regulate feeding, metabolism, gastric mobility and energy homeostasis. The pathways that mediate the effect of leptin are JAK/STAT, PI3K and JNK.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Rola Hammoud et al.
Molecular nutrition & food research, 64(9), e1901178-e1901178 (2020-02-29)
High-folic-acid diets during pregnancy result in obesity in the offspring, associated with altered DNA-methylation of hypothalamic food intake neurons. Like folic acid, the methyl-donor choline modulates foetal brain development, but its long-term programing effects on energy regulation remain undefined. This
A G Leary et al.
Blood, 75(10), 1960-1964 (1990-05-15)
Leukemia inhibitory factor (LIF)/differentiation-inhibiting activity (DIA)/human interleukin for DA cells (HILDA) is a cytokine with biologic activities involving a variety of different types of target cells. Here we have tested LIF/DIA for possible effects on the growth and differentiation of
Liwei Jiang et al.
Frontiers in immunology, 12, 730438-730438 (2022-02-04)
Lymph node (LN)-resident stromal cells play an essential role in the proper functioning of LNs. The stromal compartment of the LN undergoes significant compensatory changes to produce a milieu amenable for regulation of the immune response. We have identified a
H Baumann et al.
Journal of immunology (Baltimore, Md. : 1950), 143(4), 1163-1167 (1989-08-15)
The coordinate increase in the hepatic production of the acute phase plasma proteins appears to be mediated by several cytokines produced by different cell types. One factor, hepatocyte-stimulating factor III (HSF-III), constitutively produced by human squamous carcinoma (COLO-16) cells, stimulates
M Mori et al.
Biochemical and biophysical research communications, 160(3), 1085-1092 (1989-05-15)
A human melanoma cell line, SEKI, induces severe cachexia in tumor-bearing nude mice. A factor with the ability to inhibit lipoprotein lipase (LPL) was isolated from the conditioned medium of this cell line. This factor was 40-K-dalton protein, and designated
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