L6545

Letrozol

≥98% (HPLC), powder, non-steroidal aromatase inhibitor

• Synonym(e): 4,4′-(1H-1,2,4-Triazol-1-ylmethylen)-bisbenzonitril
• Empirische Formel (Hill-System): C₁₇H₁₁N₅
• CAS-Nummer: 112809-51-5
• Molekulargewicht: 285.30
• MDL-Nummer: MFCD00866241
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329817641
• NACRES: NA.77

Eigenschaften

• product name: Letrozol, ≥98% (HPLC)
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: >50 mg/mL
• Ersteller: Novartis
• Lagertemp.: 2-8°C
• SMILES String: N#CC(C=C1)=CC=C1C(N2C=NC=N2)C3=CC=C(C#N)C=C3
• InChI: 1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H
• InChIKey: HPJKCIUCZWXJDR-UHFFFAOYSA-N
• Angaben zum Gen: human ... CYP19A1(1588)

Beschreibung

Anwendung

Letrozole has been used:

• in organoid growth assay to determine its inhibitory capacity(48)
• to investigate steroid receptor coactivator-1 (SRC-1) mediated endogenous estrogen regulation of hippocampal PSD-95(49)
• to determine its effects on tumor-induced hyperalgesia(50)
• for hormonal manipulation in rats(51)
• to study its effects on lipocalin-2 (Lcn2)(52)
• to determine its effects on mechanical hyperalgesia and aromatase expression(53)

Biochem./physiol. Wirkung

Letrozol ist ein nicht-steroidaler Aromatase-Inhibitor der dritten Generation. Es ist ein kompetitiver Inhibitor des Aromatase Enzymsystems und verhindert so die Umwandlung von Androgenen zu Östrogenen. Letrozol hemmt Aromatase durch kompetitive Bindung an das Häm der Cytochrom-P450-Untereinheit des Enzyms, was zu einer Abnahme der Östrogen-Biosynthese in allen Geweben führt.

Letrozole acts as an adjuvant agent and is used to treat breast cancer.

Leistungsmerkmale und Vorteile

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Warning
• H-Sätze: H361fd,H373
• P-Sätze: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Repr. 2 - STOT RE 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable