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I9898

Sigma-Aldrich

Anti-Interleukin-5 antibody produced in goat

IgG fraction of antiserum, lyophilized powder

Synonym(e):

Anti-IL-5

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About This Item

MDL-Nummer:
MFCD00212216
UNSPSC-Code:
51111800
NACRES:
NA.41

Biologische Quelle

goat

Qualitätsniveau

200

Konjugat

unconjugated

Antikörperform

IgG fraction of antiserum

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Form

lyophilized powder

Speziesreaktivität

human

Methode(n)

indirect ELISA: 0.5-1.0 μg/test
neutralization: suitable
western blot: 1-2 μg/mL

UniProt-Hinterlegungsnummer

P05113

Lagertemp.

−20°C

Posttranslationale Modifikation Target

unmodified

Angaben zum Gen

human ... IL5(3567)

Allgemeine Beschreibung

The antibody neutralizes the biological activity of recombinant human IL-5.

Immunogen

recombinant human IL expressed in Sf 21 insect cell line.

Biochem./physiol. Wirkung

Interleukin-5 is a T-cell derived cytokine that induces the differentiation of B cells into antibody producing plasma cells. It is a critical differentiation factor for eosinophils and regulates the expression of genes required for cell proliferation, survival and maturation. The cellular functions of IL-5 are mediated by JAK-STAT, Btk and Ras/Raf-ERK signaling pathways. IL-5 is a good molecular target for the treatment of eosinophilic diseases.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Angaben zur Herstellung

Purified using protein G.

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Taku Kouro et al.
International immunology, 21(12), 1303-1309 (2009-10-13)
IL-5 was originally defined as a T-cell-derived cytokine that triggers activated B cells for terminal differentiation into antibody-secreting plasma cells, at least in mice. Concurrently, IL-5 was recognized as the major maturation and differentiation factor for eosinophils in mice and
Kiyoshi Takatsu
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 87(8), 463-485 (2011-10-12)
While interleukin-5 (IL-5) is initially identified by its ability to support the growth and terminal differentiation of mouse B cells in vitro into antibody-secreting cells, recombinant IL-5 exerts pleiotropic activities on various target cells including B cells, eosinophils, and basophils.
Jonathan Corren
Discovery medicine, 13(71), 305-312 (2012-05-01)
Elevated numbers of blood and tissue eosinophils are present in allergic diseases and experimental evidence suggests that eosinophils play an important pathogenic role in these conditions. Regulation of eosinophil maturation, recruitment, and survival is under the control of a small
Patricia C Fulkerson et al.
Journal of immunology (Baltimore, Md. : 1950), 193(8), 4043-4052 (2014-09-19)
Eosinophils originate in the bone marrow from an eosinophil lineage-committed, IL-5Rα-positive, hematopoietic progenitor (eosinophil progenitor). Indeed, IL-5 is recognized as a critical regulator of eosinophilia and has effects on eosinophil progenitors, eosinophil precursors, and mature eosinophils. However, substantial levels of
Qiong Long et al.
Human vaccines & immunotherapeutics, 10(8), 2303-2311 (2014-11-27)
We sought to develop an IL-33 vaccine and evaluate its efficacy in a mouse model of asthma. The full-length molecules of putative mature IL-33 were inserted into the immunodominant epitope region of hepatitis B core antigen using gene recombination techniques.
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