I7159

Monoclonal Anti-Interleukin-4 antibody produced in mouse

clone 3010, purified immunoglobulin, lyophilized powder

• Synonym(e): Anti-IL-4
• MDL-Nummer: MFCD00212213
• UNSPSC-Code: 51111800
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 3010, monoclonal
• Form: lyophilized powder
• Speziesreaktivität: human
• Methode(n): capture ELISA: suitable; western blot: 1-2 μg/mL
• Isotyp: IgG1
• UniProt-Hinterlegungsnummer: P05112
• Lagertemp.: −20°C
• Angaben zum Gen: human ... IL4(3565)

Beschreibung

Allgemeine Beschreibung

Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signalling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4 have been reported in cancers of breast, liver and renal cells
Anti-Interleukin-4 specifically recognizes human interleukin-4.

Immunogen

purified, E. coli-derived recombinant human interleukin-4.

Anwendung

Anti-Interleukin-4 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA, a working concentration of 4 μg/ml is recommended.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)