I4657

Insulin-like Growth Factor-I Receptor human

≥95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

• Synonym(e): IGF-I Receptor
• MDL-Nummer: MFCD01323726
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 200
• Rekombinant: expressed in NSO cells
• Assay: ≥95% (SDS-PAGE)
• Form: lyophilized powder
• Mol-Gew.: α-chain ~120 & 150 kDa; β subunit ~46 & 50 kDa
• Verpackung: pkg of 50 μg
• Verunreinigungen: endotoxin, tested
• UniProt-Hinterlegungsnummer: P08069
• Lagertemp.: −20°C
• Angaben zum Gen: human ... IGF1R(3480)

Beschreibung

Allgemeine Beschreibung

IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies.

Anwendung

Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.

Biochem./physiol. Wirkung

IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.

Physikalische Form

Lyophilized from a 0.2 μm solution in phosphate buffered saline.

Hinweis zur Analyse

As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.

The biological activity is measured by its ability to bind human IGF­-­I in a functional ELISA assay.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)