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I2532
Monoclonal Anti-Interleukin-7 antibody produced in mouse
clone 7417.111, purified immunoglobulin, lyophilized powder
Synonym(e):
Anti-IL-7
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About This Item
MDL-Nummer:
UNSPSC-Code:
51111800
Biologische Quelle
mouse
Konjugat
unconjugated
Antikörperform
purified immunoglobulin
Antikörper-Produkttyp
primary antibodies
Klon
7417.111, monoclonal
Form
lyophilized powder
Speziesreaktivität
human
Methode(n)
capture ELISA: suitable
neutralization: suitable
western blot: 1-2 μg/mL
Isotyp
IgG1
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... IL7(3574)
Allgemeine Beschreibung
Interleukin-7 (IL-7) is a stromal-cell derived cytokine that is important in the development of adaptive immunity and maintenance of T cells and B cells. IL-7 is produced by bone marrow cells, liver and intestinal epithelia cells, dendritic cells, smooth muscle cells, fibroblasts macrophages and keratinocytes. The effect of IL-7 is mediated by IL-7 receptor α chain and by the subsequent activation of JAK/STAT, PI3K and Src kinases. Important roles of IL-7 include proliferation of lymphoid progenitors, survival and homeostasis of naïve and memory T cells
Monoclonal Anti-Interleukin-7 recognizes recombinant human IL-7 (approximately 17 kDa).
Monoclonal Anti-Interleukin-7 recognizes recombinant human IL-7 (approximately 17 kDa).
Spezifität
The antibody has the ability to neutralize the biological activity of recombinant human IL-7. It may also be used as a capture antibody in a human IL-7 ELISA.
Immunogen
purified recombinant human IL-7, expressed in E. coli.
Anwendung
Anti-Interleukin-7 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA the working concentration recommended is 1-2 μg/ml. The antibody is also suitable for neutralization assays.
Physikalische Form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
Eyeshields, Gloves, type N95 (US)
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Modulating T cell Homeostasis with IL-7: Preclinical and Clinical Studies
Capitini CM et al
J. Int. Med., 266, 141-153 (2009)
Charles D Surh et al.
Immunological reviews, 211, 154-163 (2006-07-11)
The pool of memory T cells is regulated by homeostatic mechanisms to persist for prolonged periods at a relatively steady overall size. Recent work has shown that two members of the common gamma chain (gammac) family of cytokines, interleukin-7 (IL-7)
Shoshana D Katzman et al.
Cytokine, 56(1), 116-121 (2011-08-03)
Regulation of the magnitude and quality of immune responses is dependent on the integration of multiple signals which typically operate through positive and negative feedback loops. Cytokines that promote or limit T cell expansion and differentiation are often both present
K S Schluns et al.
Nature immunology, 1(5), 426-432 (2001-03-23)
The naïve and memory T lymphocyte pools are maintained through poorly understood homeostatic mechanisms that may include signaling via cytokine receptors. We show that interleukin-7 (IL-7) plays multiple roles in regulating homeostasis of CD8+ T cells. We found that IL-7
J T Tan et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(15), 8732-8737 (2001-07-12)
In T cell-deficient conditions, naive T cells undergo spontaneous "homeostatic" proliferation in response to contact with self-MHC/peptide ligands. With the aid of an in vitro system, we show here that homeostatic proliferation is also cytokine-dependent. The cytokines IL-4, IL-7, and
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