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Merck

I2393

Sigma-Aldrich

Interleukin-1β from rat

IL-1β, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(e):

IL-1β, Interleukin-1β from rat, Lymphocyte activating factor

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352202

Biologische Quelle

rat

Qualitätsniveau

Rekombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE and HPLC)

Form

lyophilized powder

Wirksamkeit

0.01-0.1 ng/mL ED50/EC50

Mol-Gew.

17.3 kDa

Verpackung

pkg of 10 and 50 μg

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

<0.1 EU/μg

UniProt-Hinterlegungsnummer

Lagertemp.

−20°C

Angaben zum Gen

rat ... Il1b(24494)

Verwandte Kategorien

Allgemeine Beschreibung

Interleukin-1 (IL-1), originally known as Lymphocyte Activating Factor (LAF), activates T cells and lymphocytes, which then proliferate and secrete interleukin-2.1 IL-1 is primarily released from stimulated macrophages and monocytes, but is also released from several other cell types,2 and is thought to play a key role in inflammatory and immune responses.3 Other synonyms for IL-1 include: Endogenous Pyrogen (EP), Mitogenic Protein (MP), Helper Peak-1 (HP-1), T Cell Replacing Factor III (TRF III or TRFH), B cell Activating Factor (BAF) and B Cell Differentiation Factor (BDF).4 The two closely related agents, Interleukin-1α (IL-1α) and Interleukin-1β (IL-1β) bind to the same cell surface receptor, elicit nearly identical biological responses and yet share 25% homology in their amino acid sequence. Recombinant rat IL-1β is a 17.3 kDa protein containing 153 amino acid residues.

Physikalische Form

Lyophilized from a 0.2 μm filtered buffered solution.

Hinweis zur Analyse

The biological activity is measured in a cell proliferation assay using murine D10S cells.

Quellenangabe

1. Gery, I., et al., J. Exp. Med., 136, 128 (1972).
2. Oppenheim, J. J., et al., Immunol. Today, 7, 45 (1986).
3. Durum, S. K., et al., Annu. Rev. Immunol., 3, 263 (1985).
4. Aarden, L., et al., J. Immunol., 123, 2928 (1979).
5. Symons, J., et al., Lymphokines and Interferons, A Practical Approach, Clemens, M., et al., (eds.), IRL Press, Oxford (1987).

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Wei Zhou et al.
Journal of neurophysiology, 117(6), 2282-2291 (2017-03-17)
Excessive inflammation including IL-1β-initiated signaling is among the earlies reactions that can cause neuronal damage following spinal cord injury (SCI). It has been suggested that microRNAs may participate in stem cell repair to facilitate functional recovery following SCI. In this

Artikel

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

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