I134

L-N⁵-(1-Iminoethyl)ornithine hydrochloride

≥95% (HPLC)

• Synonym(e): L-NIO hydrochloride, L-Ornithine ψ-acetamidine hydrochloride
• Empirische Formel (Hill-System): C₇H₁₅N₃O₂ · xHCl
• CAS-Nummer: 852173-80-9
• Molekulargewicht: 173.21 (free base basis)
• MDL-Nummer: MFCD00153817
• UNSPSC-Code: 12352204
• PubChem Substanz-ID: 329815348
• NACRES: NA.26

Eigenschaften

• Assay: ≥95% (HPLC)
• Form: powder
• Mol-Gew.: calculated mol wt 173.22 g/mol
• Lagerbedingungen: desiccated; under inert gas
• Farbe: white to beige
• Löslichkeit: H₂O: 2 mg/mL, clear (warmed)
• Lagertemp.: −20°C
• SMILES String: CC(NCCC[C@H](N)C(O)=O)=N.[H]Cl
• InChI: 1S/C7H15N3O2.ClH/c1-5(8)10-4-2-3-6(9)7(11)12;/h6H,2-4,9H2,1H3,(H2,8,10)(H,11,12);1H/t6-;/m0./s1
• InChIKey: JIBZSGQTCBWUKL-RGMNGODLSA-N

Beschreibung

Anwendung

L-N⁵-(1-Iminoethyl) ornithine hydrochloride has been used to study the effects of the cytotoxic drug paclitaxel and carbachol (a cholinergic agonist) to induce death in breast tumor MCF-7 cells and the role of nitric oxide synthase (NOS) in this effect. It has also been used to study its effects on pulmonary arterial responses to sufentanil in the feline pulmonary vascular bed.

Biochem./physiol. Wirkung

A potent irreversible inhibitor of nitric oxide synthase.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves