I1286

Icariin

≥94% (HPLC)

• Synonym(e): 4′-O-methyl-8-γ,γ-dimethylallylkaempferol-3-rhamnosid-7-glucosid
• Empirische Formel (Hill-System): C₃₃H₄₀O₁₅
• CAS-Nummer: 489-32-7
• Molekulargewicht: 676.66
• MDL-Nummer: MFCD00210516
• UNSPSC-Code: 12352205
• PubChem Substanz-ID: 329815347
• NACRES: NA.25

Eigenschaften

• Assay: ≥94% (HPLC)
• Farbe: light yellow to yellow
• Löslichkeit: DMSO: 50 mg/mL, clear, colorless to dark yellow
• Anwendung(en): metabolomics; vitamins, nutraceuticals, and natural products
• Lagertemp.: room temp
• SMILES String: COc1ccc(cc1)C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(=O)c4c(O)cc(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)c(C\C=C(\C)C)c4O2
• InChI: 1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1
• InChIKey: TZJALUIVHRYQQB-XLRXWWTNSA-N

Beschreibung

Allgemeine Beschreibung

Icariin is a prenylated flavonol and the major bioactive compound found in Epimedium herb.

Anwendung

Icariin has been used:

• in the preparation of topical treatment to determine its effects on the improvement of cutaneous wound healing in rats
• to test its analgesic effects on lower back pain (LBP) in rats
• as a potential treatment in osteoporosis condition in rats
• to study its effects on palmitate (PA)-induced insulin resistance in skeletal muscle C2C12 myotubes
• as a neuroprotective agent to study its effects on amyloid-β (Aβ)-induced neuronal insulin resistance in human neuroblastoma SK-N-MC cells

Biochem./physiol. Wirkung

Icariin is a potent neuroprotective agent in neurodegenerative disorders and other disorders affecting the nervous system. It elicits anti-aging properties in unfertilized oocytes against age-related damage. Icariin exerts anti-inflammatory and antifibrotic properties aiding protection in chronic kidney disease (CKD)-associated renal fibrosis in mouse model. It also serves as an excellent antidiabetic and anti-atherosclerotic agent. Icariin is an excellent anti-cancer agent.

Flavonoid glucoside derived from the the Epimedium plant genus. This pharmacologically active constituent or its derivatives have been shown to enhance bone formation, modulate multidrug resistance, enhance neuronal viability, stimulate angiogenesis, and exhibit antioxidant activity.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable