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H7660

Sigma-Aldrich

Heregulin-β1 (EGF Domain) human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym(e):

HRG-β1

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About This Item

MDL-Nummer:
MFCD03457066
UNSPSC-Code:
12352202
NACRES:
NA.32

Biologische Quelle

human

Qualitätsniveau

200

Rekombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

<0.50 ng/mL

Mol-Gew.

predicted mol wt 8 kDa

Verpackung

pkg of 10 and 50 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Verunreinigungen

endotoxin, tested

Farbe

white

UniProt-Hinterlegungsnummer

Q02297

Lagertemp.

−20°C

Angaben zum Gen

human ... NRG1(3084)

Biochem./physiol. Wirkung

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

Hinweis zur Analyse

The biological activity is measured by its ability to stimulate the proliferation of human MCF-7 cells grown under serum-free conditions.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Wei Tan et al.
The Journal of biological chemistry, 282(33), 24343-24351 (2007-06-15)
Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. Recently, altered expression of a novel isoform (type IV) in the brain has
Paul J Harrison et al.
Biological psychiatry, 60(2), 132-140 (2006-01-31)
Neuregulin 1 (NRG1) is a leading schizophrenia susceptibility gene. The NRG1 locus on chromosome 8p shows linkage to the disorder, and genetic association has been found between schizophrenia and various non-coding polymorphisms and haplotypes, especially at the 5' end of
A M Addington et al.
Molecular psychiatry, 12(2), 195-205 (2006-10-13)
Childhood-onset schizophrenia (COS), defined as onset of psychosis by the age of 12, is a rare and malignant form of the illness, which may have more salient genetic influence. Since the initial report of association between neuregulin 1 (NRG1) and
Shuji Wakatsuki et al.
Genes to cells : devoted to molecular & cellular mechanisms, 19(1), 66-77 (2013-11-22)
After peripheral nerve injury, Schwann cells gain a migratory phenotype and remodel their extracellular matrix to provide a supportive environment for axonal regeneration. The soluble neuregulin-1 isoform, that is, glial growth factor (GGF), is expressed in regenerating axons of injured

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