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H7291
Interleukin-4 human
IL-4, potency:, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
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About This Item
Empfohlene Produkte
Biologische Quelle
human
Qualitätsniveau
Rekombinant
expressed in HEK 293 cells
Assay
>95% (SDS-PAGE)
Form
lyophilized powder
Wirksamkeit
≤0.6 ng/mL EC50
Qualität
endotoxin tested
Mol-Gew.
dimer 14-19 kDa (glycosylated)
Verpackung
pkg of 1 mg
pkg of 10 μg
pkg of 100 μg
Hersteller/Markenname
HumanZyme
Methode(n)
cell culture | mammalian: suitable
Verunreinigungen
<1 EU/μg
UniProt-Hinterlegungsnummer
Lagertemp.
−20°C
Angaben zum Gen
human ... IL4(3565)
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Allgemeine Beschreibung
Interleukin-4 (IL-4) is a pleiotropic cytokine and a complex glycoprotein mapped to human chromosome 5q31.1. It is produced by mast cells, basophils and a subset of activated T cells.
Biochem./physiol. Wirkung
Interleukin-4 (IL-4) interacts with interleukin 13 and is an interleukin-4 receptor ligand. It regulates IgE and IgG1 production by B cells. IL-4 favors glial and neuronal differentiation and regulates differentiation of naive cluster of differentiation CD4+ T cells to the T helper type 2 (TH2) cells. Polymorphism in the IL-4 gene is implicated in immune and inflammatory disorders. In cerebral infarction, IL-4 levels are elevated.
Physikalische Form
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
Angaben zur Herstellung
HumanKine Interleukin-4 (IL-4), expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 14-19 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Hinweis zur Analyse
The activity is determined by the dose-dependent simulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
Rechtliche Hinweise
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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