H127

p-Fluorohexahydro-sila-difenidol hydrochloride

powder, ≥98% (HPLC)

• Synonym(e): Cyclohexyl-(4-fluorophenyl)-(3-N-piperidinopropyl)silanol hydrochloride, P-F-HHSiD hydrochloride
• Empirische Formel (Hill-System): C₂₀H₃₂FNOSi · HCl
• CAS-Nummer: 116679-83-5
• Molekulargewicht: 386.02
• MDL-Nummer: MFCD00078582
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277841
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: H₂O: slightly soluble 1.5 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >14 mg/mL; ethanol: soluble
• SMILES String: Cl[H].O[Si](CCCN1CCCCC1)(C2CCCCC2)c3ccc(F)cc3
• InChI: 1S/C20H32FNOSi.ClH/c21-18-10-12-20(13-11-18)24(23,19-8-3-1-4-9-19)17-7-16-22-14-5-2-6-15-22;/h10-13,19,23H,1-9,14-17H2;1H
• InChIKey: JMTYYLMGSBSPPK-UHFFFAOYSA-N
• Angaben zum Gen: human ... CHRM3(1131)

Beschreibung

Anwendung

p-Fluorohexahydro-sila-difenidol hydrochloride (pFHHSid) has been used:

• as the M3/muscarinic acetylcholine receptor antagonist to study its involvement in carbachol induced Egr-1 biosynthesis using human neuroblastoma cells
• as M3 receptor antagonist to test its involvement on N,N-diethyl-m-toluamide (DEET)-induced angiogenesis in human umbilical venous endothelial cells (HUVEC)
• in a study to examine the role of aclidinium on human fibroblast to myofibroblast

Biochem./physiol. Wirkung

High affinity M₃ muscarinic acetylcholine receptor antagonist.

Leistungsmerkmale und Vorteile

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)