G3545

GW583340 dihydrochloride

≥97% (HPLC), solid

• Synonym(e): 4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride
• Empirische Formel (Hill-System): C₂₈H₂₅ClFN₅O₃S₂ · 2HCl
• CAS-Nummer: 1173023-85-2
• Molekulargewicht: 671.03
• MDL-Nummer: MFCD07370137
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 24895131
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: solid
• mp (Schmelzpunkt): 259.8-262.4 °C (lit.)
• Löslichkeit: DMSO: 9 mg/mL
• Ersteller: GlaxoSmithKline
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].Cl[H].CS(=O)(=O)CCNCc1nc(cs1)-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2
• InChI: 1S/C28H25ClFN5O3S2.2ClH/c1-40(36,37)10-9-31-14-27-35-25(16-39-27)19-5-7-24-22(12-19)28(33-17-32-24)34-21-6-8-26(23(29)13-21)38-15-18-3-2-4-20(30)11-18;;/h2-8,11-13,16-17,31H,9-10,14-15H2,1H3,(H,32,33,34);2*1H
• InChIKey: WIMITXDBYLKRKB-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Potent dual ErbB-2/EGFR tyrosine kinase inhibitor. IC₅₀= 0.01 and 0.014 μM for EGFR and ErbB-2. Orally active.

Leistungsmerkmale und Vorteile

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rechtliche Hinweise

Sold for research purposes under agreement from Glaxo­Smith­Kline

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves