F5557

Fasentin

≥98% (HPLC)

• Synonym(e): N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide
• Empirische Formel (Hill-System): C₁₁H₉ClF₃NO₂
• CAS-Nummer: 392721-37-8
• Molekulargewicht: 279.64
• MDL-Nummer: MFCD01001285
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329799713
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: >10 mg/mL
• Lagertemp.: room temp
• SMILES String: CC(=O)CC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
• InChI: 1S/C11H9ClF3NO2/c1-6(17)4-10(18)16-7-2-3-9(12)8(5-7)11(13,14)15/h2-3,5H,4H2,1H3,(H,16,18)
• InChIKey: GNYIJZMBLZXJEJ-UHFFFAOYSA-N

Beschreibung

Anwendung

Fasentin has been used as a glucose transporter (GLUT1) inhibitor to assess its effects on the vulnerability of a wide range of triple-negative breast cancer (TNBC) cell lines and to study its effects on cytotoxic drugs induced by hydrocortisone (HC).

Biochem./physiol. Wirkung

Fasentin is a novel inhibitor of glucose uptake, GluT1 inhibitor. Fasentin is a novel inhibitor of glucose uptake that sensitizes cells to FAS-induced cell death. Fasentin selectively sensitized to death ligands, but did not decrease FLIP expression. It alters expression of genes associated with nutrient and glucose deprivation. Fasentin interacted with a unique site in the intracellular channel of the glucose transport protein GLUT1.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable