F5132
Factor II from human plasma
lyophilized powder, 5-20 units/mg protein
Synonym(e):
Prothrombin
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About This Item
Form
lyophilized powder
Spezifische Aktivität
5-20 units/mg protein
UniProt-Hinterlegungsnummer
Fremdaktivität
factor X <0.01% of base activity
thrombin, none detected
Lagertemp.
−20°C
Angaben zum Gen
human ... F2(2147)
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Biochem./physiol. Wirkung
Plasma phospholipid binding protein; binds to endothelial cells, promotes clotting on the cell surfaces.
Einheitendefinition
One unit is the amount contained in one mL of normal human plasma.
Rekonstituierung
When reconstituted with 1 ml of deionized water, solution will contain the indicated activity in 0.5 M NaCl, 0.05 M Tris-HCl, pH 8.0.
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Maria M Aleman et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(8), 1829-1836 (2013-06-01)
Individuals with elevated prothrombin, including those with the prothrombin G20210A mutation, have increased risk of venous thrombosis. Although these individuals do not have increased circulating prothrombotic biomarkers, their plasma demonstrates increased tissue factor-dependent thrombin generation in vitro. The objectives of
Yuichiro Yanagida et al.
Surgery, 154(1), 48-57 (2013-05-21)
We tested the hypotheses that an increase in systemic thrombin activity occurs in both disseminated intravascular coagulation (DIC) with the fibrinolytic phenotype and in acute coagulopathy of trauma shock (ACoTS), and that the patients diagnosed as having ACoTS overlap or
Masahiko Tameda et al.
Cancer science, 104(6), 725-731 (2013-03-14)
Serum tumor markers, including α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), are currently used in the diagnosis of hepatocellular carcinoma (HCC). There is, however, an aberrant increase in serum DCP in patients with obstructive jaundice, vitamin K deficiency or who are
Marc A Bailey et al.
Journal of vascular surgery, 57(6), 1512-1518 (2013-03-16)
Abdominal aortic aneurysm (AAA) is associated with hypercoagulability, evidenced by increased markers of coagulation activation, including thrombin-antithrombin complex (TAT), prothrombin fragments 1 and 2 (F1+2), and D-dimer. Our aim was to compare the effect of endovascular aneurysm repair (EVAR) and
Atsushi Nanashima et al.
Anticancer research, 33(6), 2689-2697 (2013-06-12)
Although the protein-induced vitamin K absence or antagonist-II (PIVKA-II) is used as a prognostic marker in hepatocellular carcinoma (HCC), a newly-improved assay, NX-PVKA (PIVKA-II measured using P-11 and P-16 antibodies) and NX-PVKA-R (ratio of PIVKA-II and NX-PVKA), are more accurate
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