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E1279

Sigma-Aldrich

Enoximone

solid

Synonym(e):

1,3-Dihydro-4-methyl-5-(4-methylthiobenzoyl)-2H-imidazol-2-one

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About This Item

Empirische Formel (Hill-System):
C12H12N2O2S
CAS-Nummer:
77671-31-9
Molekulargewicht:
248.30
MDL-Nummer:
MFCD00867130
UNSPSC-Code:
41106305
PubChem Substanz-ID:
24278408
NACRES:
NA.77

Form

solid

Farbe

light yellow

Löslichkeit

DMSO: soluble 28 mg/mL

SMILES String

CSc1ccc(cc1)C(=O)C2=C(C)NC(=O)N2

InChI

1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)

InChIKey

ZJKNESGOIKRXQY-UHFFFAOYSA-N

Angaben zum Gen

human ... PDE3A(5139) , PDE3B(5140)

Biochem./physiol. Wirkung

Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.

Leistungsmerkmale und Vorteile

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Analysenzertifikate (COA)

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S Schauvliege et al.
Equine veterinary journal, 41(8), 778-785 (2010-01-26)
No studies have been reported on the effects of enoximone in anaesthetised colic horses. To examine whether enoximone improves cardiovascular function and reduces dobutamine requirement in anaesthetised colic horses. Forty-eight mature colic horses were enrolled in this prospective, randomised clinical
H J Gilfrich et al.
Zeitschrift fur Kardiologie, 80 Suppl 4, 93-97 (1991-01-01)
Enoximone, a new phosphodiesterase-inhibitor with positive inotropic and vasodilating activities is available for intravenous use in patients with severe heart failure. A review of the current knowledge regarding the adverse effects of this substance reveals that they are characterized by
B Hausen et al.
European heart journal, 13(5), 679-686 (1992-05-01)
Inotropic support is often required for post-operative management of patients following mitral valve operation. The use of positive inotropes is limited by tolerance development and increase in myocardial oxygen demand. We have compared i.v. enoximone (E) (group E, n =
Paolo Nardi et al.
The Annals of thoracic surgery, 87(5), 1401-1407 (2009-04-22)
Coronary artery bypass grafting (CABG) is a well-accepted therapeutic strategy for patients with multivessel coronary artery disease and left ventricular dysfunction. The aim of the study was to evaluate long-term results after CABG in patients with preoperative left ventricular ejection
Stijn Schauvliege et al.
Veterinary anaesthesia and analgesia, 36(3), 197-208 (2009-04-29)
To compare cardiac output () measurements using lithium dilution (LiDCO) and pulse contour analysis (PulseCO) techniques in isoflurane-anaesthetized ponies before and during the administration of different inotropic/vasoactive drugs. Prospective randomized experimental cross-over trial. Six ponies aged 5.0 +/- 1.6 (4-6.5)
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