E0907

Anti-phospho-Epidermal Growth Factor Receptor (pTyr⁸⁴⁵) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(e): Anti-phospho-EGFR (pTyr⁸⁴⁵)
• MDL-Nummer: MFCD03845329
• UNSPSC-Code: 51111800

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: lyophilized powder
• Speziesreaktivität: human
• Methode(n): flow cytometry: 5 μg/mL; immunohistochemistry: 15 μg/mL; western blot: 0.5 μg/mL
• UniProt-Hinterlegungsnummer: P00533
• Lagertemp.: −20°C
• Angaben zum Gen: human ... EGFR(1956)

Beschreibung

Immunogen

purified, synthetic phosphopeptide corresponding to residues surrounding tyrosine 845 of human epidermal growth factor receptor.

Biochem./physiol. Wirkung

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer. Phosphorylation of Tyr845 is associated with EGFR mutation and serves as a surrogate marker.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)