E0656

ER-27319

≥98% (HPLC), solid

• Synonym(e): 10-(3-Aminopropyl)-3,4-dimethyl-9-acridone oxalate
• Empirische Formel (Hill-System): C₂₀H₂₂N₂O₅
• CAS-Nummer: 201010-95-9
• Molekulargewicht: 370.40
• MDL-Nummer: MFCD07784502
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724472
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: solid
• Löslichkeit: DMSO: 28 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: OC(=O)C(O)=O.Cc1ccc2C(=O)c3ccccc3N(CCCN)c2c1C
• InChI: 1S/C18H20N2O.C2H2O4/c1-12-8-9-15-17(13(12)2)20(11-5-10-19)16-7-4-3-6-14(16)18(15)21;3-1(4)2(5)6/h3-4,6-9H,5,10-11,19H2,1-2H3;(H,3,4)(H,5,6)
• InChIKey: IIELZHYJYZBSGG-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

ER-27319 inhibits Syk activation with an IC₅₀ = 10 μM. ER-27319 inhibits Syk by preventing the phosphorylated ITAM domain of FcεRI γ from activating Syk. ER-27319 does NOT inhibit previously activated Syk.

Selective Syk inhibitor. Induces tyrosine phosphorylation of Syk that has been demonstrated as critical for degranulation.

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302 + H312
• P-Sätze: P264 - P280 - P301 + P312 - P302 + P352 + P312 - P362 + P364 - P501
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable