E0409

Monoclonal Anti-EDEM3 antibody produced in mouse

~1.0 mg/mL, clone EDEM3-1, purified immunoglobulin, buffered aqueous solution

• Synonym(e): Anti-ER degradation enhancer, mannosidase α-like 3
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: EDEM3-1, monoclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen ~120 kDa
• Speziesreaktivität: rat, mouse, human
• Konzentration: ~1.0 mg/mL
• Methode(n): western blot: 1-2 μg/mL using whole extract of mouse 3T3 or rat NRK cells
• UniProt-Hinterlegungsnummer: Q9BZQ6
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... EDEM3(80267) ; mouse ... Edem3(66967) ; rat ... Edem3(289085)

Beschreibung

Allgemeine Beschreibung

Monoclonal Anti-EDEM3 (mouse IgG1 isotype) is derived from the hybridoma EDEM3-1 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human EDEM3 conjugated to KLH.

Three EDEM homologs, EDEM1, EDEM2 and EDEM3 have been identified, which are transcriptionally upregulated upon ER stress by the activated IRE1/Xbp-1 branch.

Anwendung

Monoclonal Anti-EDEM3 antibody produced in mouse has been used in immunoblotting.

Biochem./physiol. Wirkung

EDEM3 (ER degradation enhancer, mannosidase α-like 3), a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation (ERAD) and mannose trimming. EDEM3 accelerates ERAD of misfolded glycoproteins as well, but in ontrast to EDEM1, it greatly stimulates mannosidase trimming in vivo.

Physikalische Form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable