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Merck

D9571

Sigma-Aldrich

Dolasetron mesylate hydrate

≥98% (HPLC), powder

Synonym(e):

Anzemet hydrate, Dolasetron methanesulfonate hydrate

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About This Item

Empirische Formel (Hill-System):
C19H20N2O3 · CH4O3S · xH2O
CAS-Nummer:
Molekulargewicht:
420.48 (anhydrous basis)
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Farbe

white to off-white

Löslichkeit

H2O: >30 mg/mL

Ersteller

Sanofi Aventis

Lagertemp.

2-8°C

SMILES String

O.CS(O)(=O)=O.O=C1CN2[C@@H]3C[C@H](C[C@H]2CC1C3)OC(=O)c4c[nH]c5ccccc45

InChI

1S/C19H20N2O3.CH4O3S.H2O/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17;1-5(2,3)4;/h1-4,9,11-14,20H,5-8,10H2;1H3,(H,2,3,4);1H2/t11?,12-,13+,14+;;

InChIKey

QTFFGPOXNNGTGZ-BHSFMSKKSA-N

Biochem./physiol. Wirkung

Dolasetron mesylate hydrate is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.

Leistungsmerkmale und Vorteile

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Christopher M Peters et al.
Brain research, 1352, 83-93 (2010-07-20)
The balance between descending inhibition and facilitation is thought to be disturbed in chronic pain states. Increased facilitation by spinally released serotonin has been suggested by demonstration that mechanically evoked neuronal responses of wide dynamic range neurons are inhibited by
Sarah Turner et al.
Journal of clinical anesthesia, 19(8), 622-625 (2007-12-18)
A 52-year-old woman with hypertension and Graves' disease was scheduled for surgical removal of a meningioma. Intraoperative events were significant for hypotension requiring a vasopressin infusion. Prophylactic dolasetron was administered to the patient before emergence. The patient's trachea was easily
Dolasetron and QT interval.
C Page et al.
Emergency medicine journal : EMJ, 25(10), 706-706 (2008-10-10)
Antiemetic agents.
Gail Wilkes
Oncology (Williston Park, N.Y.), 21(8 Suppl), 48-48 (2007-09-12)
[Palonosetron in the prevention of chemotherapy-induced nausea and vomiting (CINV) in Italy: pharmacologic, clinical and economic aspects].
Lorenzo Pradelli et al.
Tumori, 94(2), suppl 26-suppl 32 (2008-06-21)

Artikel

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