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D4889

Sigma-Aldrich

Desoxyribonukleinsäure Natriumsalz aus E. coli Stamm B

Genomic, unsheared

Synonym(e):

DNA

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About This Item

CAS-Nummer:
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41106310
eCl@ss:
32160414
NACRES:
NA.52

Qualität

Molecular Biology
for molecular biology

Qualitätsniveau

Form

lyophilized powder

Mol-Gew.

>45 kb

Lagertemp.

2-8°C

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Allgemeine Beschreibung

Escherichia coli strain B is most widely studied DNA after k-12. The genomes of E coli strain B and k-12 show differences in the IS sequence elements. Strain B have B-islands and express O-specific side-chain LPS. The product is unsheared genomic DNA.

Spezifität

50% GC; Tm = 90.5 °C

Anwendung

The DNAs are particularly useful for genomic analysis, including PCR, library construction in bacteriophage λ, and in heterologous pre-hybridization and hybridization protocols.
Deoxyribonucleic acid sodium salt from Escherichia coli strain B has been used for:
  • PCR reactions of genomic DNA of Gardnerella vaginalis
  • nick translation and radiolabeling of dNTP
  • generating standard curve for 16S rDNA quantification
  • transfecting neutrophils
  • testing the extraction methods

Einheitendefinition

One unit will yield an A260 of 1.0 in 1.0 ml of 1 mM Tris-HCl, pH 7.5, with 1 mM NaCl and 1 mM EDTA (1 cm light path).

Angaben zur Herstellung

Purified by anion exchange chromatography, dialyzed against a solution of 1 mM sodium chloride, 1 mM EDTA and 1 mM Trizma HCl, pH 7.5 and lyophilized at a concentration of approx. 2 units per mL. Approx. 20 A260 units per mg DNA. % GC is the percentage of G/C base pairs. Tm is the temperature at the midpoint of the thermal denaturation profile.

Hinweis zur Analyse

Analyzed by gel electrophoresis and visualization after ethidium bromide staining, with single predominant band of 45 kB or greater.

Sonstige Hinweise

DNA in solution will reanneal on standing at room temperature so it is recommended to boil the solution for 10 minutes and then cool on ice for at least 5 minutes prior to use.

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Jong-Pyo Kang et al.
Archives of microbiology, 201(1), 99-105 (2018-09-28)
A novel bacterial strain designated DCY116T was isolated from ginseng-cultivated soil in Gochang-gun, Republic of Korea. Strain DCY116T, belongs to the genus Rhizobium, and is closely related to Rhizobium yantingense H66T (98.3%), Neorhizobium huautlense S02T (98.2%), Rhizobium soli DS-42T (98.1%)
Vitalii Patsula et al.
Nanotoxicology, 13(4), 510-526 (2019-02-02)
Innovative nanotechnology aims to develop particles that are small, monodisperse, smart, and do not cause unintentional side effects. Uniform magnetic Fe3O4 nanoparticles (12 nm in size) were prepared by thermal decomposition of iron(III) oleate. To make them colloidally stable and dispersible
S Farzaneh et al.
The Journal of antimicrobial chemotherapy, 40(6), 789-795 (1998-02-14)
Klebsiella oxytoca strain HB60 is highly resistant to cefoperazone and aztreonam (MICs = 128 mg/L). It produces a chromosomally encoded beta-lactamase of pI 5.7 which was highly efficient against penicillins, first-generation cephalosporins and cefoperazone, a non-oxyimino third-generation cephalosporin. Aztreonam and
Xuewen Pan et al.
Methods (San Diego, Calif.), 41(2), 206-221 (2006-12-27)
Analysis of genetic interactions has been extensively exploited to study gene functions and to dissect pathway structures. One such genetic interaction is synthetic lethality, in which the combination of two non-lethal mutations leads to loss of organism viability. We have
Genomic comparisons among Escherichia coli strains B, K-12, and O157: H7 using IS elements as molecular markers
Schneider D, et al.
BMC Microbiology, 2(1), 18-18 (2002)

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