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D2396

Sigma-Aldrich

Dimenhydrinat

Synonym(e):

N-(2-Diphenylmethoxyethyl)-N,N-dimethylammonium 8-chlortheophyllinat

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About This Item

Empirische Formel (Hill-System):
C17H21NO · C7H7ClN4O2
CAS-Nummer:
523-87-5
Molekulargewicht:
469.96
EG-Nummer:
208-350-8
MDL-Nummer:
MFCD00054265
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329798738
NACRES:
NA.77

Form

powder

SMILES String

CN1C(=O)N(C)c2nc(Cl)[nH]c2C1=O.CN(C)CCOC(c3ccccc3)c4ccccc4

InChI

1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10)

InChIKey

NFLLKCVHYJRNRH-UHFFFAOYSA-N

Angaben zum Gen

human ... HRH1(3269)

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Allgemeine Beschreibung

Dimenhydrinate is a salt of antihistamine drugs, such as diphenhydramine and 8-chlorotheophylline. It has antiemetic properties. Dimenhydrinate is used to treat nausea and vomiting during pregnancy.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Serge Gouin et al.
Pediatrics, 129(6), 1050-1055 (2012-05-16)
To evaluate the efficacy and safety of oral dimenhydrinate in the treatment of acute gastroenteritis. This was a randomized, double-blind, placebo-controlled trial conducted in the emergency department of a pediatric university-affiliated center. Children 1 to 12 years old who presented
Gerard Nobel et al.
Brain research bulletin, 82(3-4), 193-200 (2010-04-17)
Motion sickness (MS) exaggerates body cooling during cold-water immersion. The aim of the present study was to investigate whether such MS-induced predisposition to hypothermia is influenced by two anti-MS drugs: the histamine-receptor blocker dimenhydrinate (DMH) and the muscarine-receptor blocker scopolamine
Faisal Karmali et al.
Journal of vestibular research : equilibrium & orientation, 20(1), 31-43 (2010-06-18)
Commercial sub-orbital operators will soon offer the excitement of traveling to space to thousands of people. Based on previous experience in space flight and parabolic flight, sensorimotor disruptions in eye movements, postural stability, and motor coordination are likely in these
Ulrike Uhlig et al.
Pediatrics, 124(4), e622-e632 (2009-09-16)
Vomiting is a common symptom in children with infectious gastroenteritis. It contributes to fluid loss and is a limiting factor for oral rehydration therapy. Dimenhydrinate has traditionally been used for children with gastroenteritis in countries such as Canada and Germany.
Matthias Voigt et al.
Journal of clinical anesthesia, 23(6), 461-468 (2011-09-14)
To evaluate strategies to treat postoperative nausea and vomiting (PONV) in patients undergoing elective breast surgery. Prospective, randomized, double-blinded, placebo-controlled trial. University-affiliated hospital. 480 patients with risk factors for PONV. Patients were randomized to three groups to receive an antiemetic
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