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D1414

Sigma-Aldrich

Droperidol

Synonym(e):

1-[1-[3-(p-Fluorbenzoyl)-propyl]-1,2,3,6-tetrahydro-4-pyridyl]-2-benzimidazolinon

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About This Item

Empirische Formel (Hill-System):
C22H22FN3O2
CAS-Nummer:
548-73-2
Molekulargewicht:
379.43
EG-Nummer:
208-957-8
MDL-Nummer:
MFCD00083290
UNSPSC-Code:
41116107
PubChem Substanz-ID:
24278357
NACRES:
NA.77

Form

powder

Ersteller

Johnson & Johnson

Lagertemp.

2-8°C

SMILES String

Fc1ccc(cc1)C(=O)CCCN2CCC(=CC2)N3C(=O)Nc4ccccc34

InChI

1S/C22H22FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-11H,3,6,12-15H2,(H,24,28)

InChIKey

RMEDXOLNCUSCGS-UHFFFAOYSA-N

Angaben zum Gen

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , KCNH1(3756) , KCNH2(3757)

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Biochem./physiol. Wirkung

D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic.
Droperidol is a potent antagonist of dopamine subtype 2 receptor. It is an antipsychotic, which is used to treat acute behavioral anomalies. It helps to manage postoperative nausea and vomiting.

Leistungsmerkmale und Vorteile

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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The safety and effectiveness of droperidol for sedation of acute behavioral disturbance in the emergency department
Calver L, et al.
Annals of Emergency Medicine, 66(3), 230-238 (2015)
A Hamik et al.
Cancer chemotherapy and pharmacology, 24(5), 307-310 (1989-01-01)
The affinities of 11 drugs for both dopamine D2 and 5-hydroxytryptamine3 (5-HT3) receptor sites were determined in brain membranes. The five "traditional" antiemetics (chlorpromazine, prochlorperazine, droperidol, fluphenazine, and domperidone) displayed high affinity (less than 20 nM) for dopamine D2 receptors
Gregory A Nuttall et al.
Anesthesiology, 118(2), 382-386 (2013-01-08)
The Food and Drug Administration issued a black box warning regarding the use of droperidol and the potential for torsade de pointes. The primary objective of this retrospective study was to determine if low-dose (0.625 mg) droperidol administration was associated
Christopher Spevak et al.
Pain medicine (Malden, Mass.), 13(8), 1072-1080 (2012-06-12)
The most feared drug-induced complication is fatal cardiac arrest. Torsades de pointes (TdP) is a polymorphic ventricular tachycardia occurring in the setting of a QT interval prolongation and is the most frequent type of drug-induced pro-arrhythmia. The most common mechanism
Esther W Chan et al.
Annals of emergency medicine, 61(1), 72-81 (2012-09-18)
Parenteral benzodiazepines or antipsychotics are often used to manage acute agitation in emergency department (ED) settings in which alternative strategies have failed or are not feasible. There are scant data comparing parenteral medication regimens. We aim to determine the efficacy
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