C7861

Citalopram -hydrobromid

≥98% (HPLC), powder, serotonin uptake inhibitor

• Synonym(e): 1-[3-(Dimethylamino)-propyl]-1-(4-fluorphenyl)-1,3-dihydro-5-isobenzofurancarbonitril -hydrobromid
• Empirische Formel (Hill-System): C₂₀H₂₁FN₂O · HBr
• CAS-Nummer: 59729-32-7
• Molekulargewicht: 405.30
• EG-Nummer: 261-890-6
• MDL-Nummer: MFCD02101306
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278335
• NACRES: NA.77

Eigenschaften

• product name: Citalopram -hydrobromid, ≥98% (HPLC)
• Qualitätsniveau: 200
• Assay: ≥98% (HPLC)
• Form: powder
• Löslichkeit: chloroform: soluble; methanol: soluble
• Ersteller: Forest Labs
• Lagertemp.: 2-8°C
• SMILES String: Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
• InChI: 1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
• InChIKey: WIHMBLDNRMIGDW-UHFFFAOYSA-N
• Angaben zum Gen: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

Beschreibung

Allgemeine Beschreibung

Citalopram is a bicyclic phthalene derivative. It initiates serotonergic activity, which produces antidepressant action. Citalopram hydrobromide reverses memory impairment. It is used to treat obsessive compulsive disorder, panic disorder, sociophobia and premenstrual dysphoric disorder.

Anwendung

Citalopram hydrobromide has been used:

• to examine its effects on sirt mRNA and mammalian sirtuins (SIRT) expression in mice
• to monitor body temperature and antidepressant-like behavioral responses in the forced swim test for rats
• for 5-hydroxytryptamine (5-HT) competition uptake assays

Biochem./physiol. Wirkung

Wirksamer und selektiver Serotonin-Aufnahme-Hemmer (K_i = 5.4 nM); Antidepressivum

Leistungsmerkmale und Vorteile

This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H302,H336,H361d,H412
• P-Sätze: P202 - P261 - P264 - P273 - P301 + P312 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3
• Zielorgane: Central nervous system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)