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C4911

Sigma-Aldrich

Chlorothiazid

thiazide diuretic

Synonym(e):

6-Chlor-2H-1,2,4-benzothiadiazin-7-sulfonamid-1,1-dioxid

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About This Item

Empirische Formel (Hill-System):
C7H6ClN3O4S2
CAS-Nummer:
58-94-6
Molekulargewicht:
295.72
EG-Nummer:
200-404-9
MDL-Nummer:
MFCD00058576
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24278150
NACRES:
NA.77

Biologische Quelle

synthetic (organic)

Assay

≥98% (HPLC)

Form

powder

mp (Schmelzpunkt)

>300 °C

Löslichkeit

DMF: 50 mg/mL, clear, colorless to very faintly yellow

Lagertemp.

2-8°C

SMILES String

O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O

InChI

1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)

InChIKey

JBMKAUGHUNFTOL-UHFFFAOYSA-N

Angaben zum Gen

human ... CA1(759) , CA4(762) , SLC12A3(6559)

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Allgemeine Beschreibung

Chlorothiazide (CTLD) is a thiazide-like diuretics and has antihypertensive effects.

Anwendung

Chlorothiazide has been used as a reference standard in parallel artificial membrane permeability assay (PAMPA). It has also been used to test its effect on blocking pendrin activity.
Einer der ersten in der Gruppe der Thiazid-Diuretika.

Biochem./physiol. Wirkung

Chlorothiazide (CTLD) shows structural resemblance with hydrochlorothiazide by having a sulfonamide group, but exhibits a long action duration. CTLD is an inhibitor of carbonic anhydrase and is more potent than hydrochlorothiazide.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H317,H334

Gefahreneinstufungen

Resp. Sens. 1 - Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Analysenzertifikate (COA)

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Furosemid

Sigma-Aldrich

F4381

Furosemid

Stela Dineva et al.
Journal of human hypertension, 33(11), 766-774 (2019-10-09)
Hypertension is a complex syndrome of multiple hemodynamic, neuroendocrine, and metabolic abnormalities. The goals of treatment in hypertension are to optimally control high blood pressure and to reduce associated cardiovascular morbidity and mortality using the most suitable therapy available. Hydrochlorothiazide
Emanuele Bernardinelli et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 38(5), 1984-1998 (2016-05-11)
Pendrin is a Cl-/I-/HCO3- exchanger playing a fundamental role in controlling blood pressure and airway function, therefore representing an attractive target for the treatment of hypertensive states and respiratory distresses. A review of the literature regarding the ability of some
Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: application to dibenz [b, f] azepine-5-carboxamide derivatives
Fortuna A, et al.
Journal of Pharmaceutical Sciences, 101(2), 530-540 (2012)
Najat Ahmed Al-Odaini et al.
Journal of chromatography. A, 1217(44), 6791-6806 (2010-09-21)
Pollutants such as human pharmaceuticals and synthetic hormones that are not covered by environmental legislation have increasingly become important emerging aquatic contaminants. This paper reports the development of a sensitive and selective multi-residue method for simultaneous determination and quantification of
Krzysztof J Paluch et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 42(3), 220-229 (2010-12-01)
Chlorothiazide (CTZ) is a poorly soluble diuretic agent. The aim of the present work was to produce and characterise a potassium salt form of chlorothiazide which has the potential advantages of improved aqueous solubility and potassium supplementation. A number of
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