C2499

CP-339818

≥98% (HPLC)

• Synonym(e): N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine hydrochloride
• Empirische Formel (Hill-System): C₂₁H₂₄N₂ · HCl
• CAS-Nummer: 478341-55-8
• Molekulargewicht: 340.89
• MDL-Nummer: MFCD09878238
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329775008
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: >10 mg/mL
• Ersteller: Wyeth
• Lagertemp.: 2-8°C
• SMILES String: Cl.CCCCC\N=C1/C=CN(Cc2ccccc2)c3ccccc13
• InChI: 1S/C21H24N2.ClH/c1-2-3-9-15-22-20-14-16-23(17-18-10-5-4-6-11-18)21-13-8-7-12-19(20)21;/h4-8,10-14,16H,2-3,9,15,17H2,1H3;1H/b22-20+;
• InChIKey: JIRISCAPZWLWCG-QPNALZDCSA-N

Beschreibung

Biochem./physiol. Wirkung

CP-338818 blocks both Kv1.3 and Kv1.4. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain cells. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. CP-339818 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. CP-339818 is also valuable for the study of Kv1.4 function.

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable