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B4636

Sigma-Aldrich

Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin

protein C substrate, ≥98% (HPLC), powder

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About This Item

Empirische Formel (Hill-System):
C34H52N8O10
CAS-Nummer:
73554-93-5
Molekulargewicht:
732.82
MDL-Nummer:
MFCD00080226
UNSPSC-Code:
12352204
PubChem Substanz-ID:
24891793
NACRES:
NA.32

product name

Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin, protein C substrate

Qualitätsniveau

200

Assay

≥98% (HPLC)

Form

powder

Löslichkeit

ethanol: 2 mg/mL, clear, colorless

Lagertemp.

−20°C

SMILES String

CC(C)CC(NC(=O)OC(C)(C)C)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CCCNC(N)=N)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C34H52N8O10/c1-17(2)13-23(41-33(50)52-34(5,6)7)29(47)40-24(16-43)30(48)42-27(19(4)44)31(49)39-22(9-8-12-37-32(35)36)28(46)38-20-10-11-21-18(3)14-26(45)51-25(21)15-20/h10-11,14-15,17,19,22-24,27,43-44H,8-9,12-13,16H2,1-7H3,(H,38,46)(H,39,49)(H,40,47)(H,41,50)(H,42,48)(H4,35,36,37)

InChIKey

ZJNWKMRGENOMCV-UHFFFAOYSA-N

Substrate

A fluorogenic substrate for activated protein C.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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H Sawada et al.
The Journal of experimental zoology, 254(1), 83-87 (1990-04-01)
Enzymatic properties of a protease involved in hatching of mouse embryos were examined. A trypsin-like protease, which most efficiently hydrolyzed t-butoxycarbonyl-Leu-Ser-Thr-Arg-4-methylcoumaryl-7-amide, was demonstrated in culture medium of mouse hatching embryos. The enzyme was strongly inhibited by diisopropyl fluorophosphate, phenylmethanesulfonyl fluoride
Brian T O'Neill et al.
The Journal of clinical investigation, 126(9), 3433-3446 (2016-08-16)
Diabetes strongly impacts protein metabolism, particularly in skeletal muscle. Insulin and IGF-1 enhance muscle protein synthesis through their receptors, but the relative roles of each in muscle proteostasis have not been fully elucidated. Using mice with muscle-specific deletion of the
Y Ohno et al.
Journal of biochemistry, 90(5), 1387-1395 (1981-11-01)
Protein C is a precursor of plasma serine proteinases, and its active form inactivates specifically blood coagulation Factor V and Factor VIII. Since a specific and sensitive synthetic substrate for the activated protein C was not known, we studied its
Ming Li et al.
Ecotoxicology and environmental safety, 135, 24-31 (2016-09-28)
Avermectins (AVMs) are used worldwide in agriculture and veterinary medicine. Residues of avermectin drugs, causing toxicological effects on non-target organisms, have raised great concern. The aim of this study was to investigate the effects of AVM on the expression levels
Mikhail Ryzhikov et al.
Cell reports, 26(7), 1880-1892 (2019-02-14)
Circadian rhythms are a hallmark of physiology, but how such daily rhythms organize cellular catabolism is poorly understood. Here, we used proteomics to map daily oscillations in autophagic flux in mouse liver and related these rhythms to proteasome activity. We
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