B2186

BL-1249

≥98% (HPLC)

• Synonym(e): (5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine
• Empirische Formel (Hill-System): C₁₇H₁₇N₅
• CAS-Nummer: 18200-13-0
• Molekulargewicht: 291.35
• MDL-Nummer: MFCD08276915
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24724415
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Lagerbedingungen: protect from light
• Farbe: pink to brown
• Löslichkeit: DMSO: ~17.5 mg/mL; H₂O: insoluble
• Lagertemp.: −20°C
• SMILES String: C1CCc2c(C1)cccc2Nc3ccccc3-c4nnn[nH]4
• InChI: 1S/C17H17N5/c1-2-8-13-12(6-1)7-5-11-15(13)18-16-10-4-3-9-14(16)17-19-21-22-20-17/h3-5,7,9-11,18H,1-2,6,8H2,(H,19,20,21,22)
• InChIKey: YYNRZIFBTOUICE-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

BL-1249 is a non-steroid anti-inflammatory drug and an inhibitor of the cyclooxygenase (COX) enzyme.

Anwendung

BL-1249 has been used:

• as an activator of mechano-gated K2P channel in contracted mouse ileum and colon tissues
• as a TWIK related potassium channel (TREK2) modulator and in U-2 OS osteosarcoma cell line
• as a TREK1 and TREK2 activator in mice.

Biochem./physiol. Wirkung

BL-1249 also activates TWIK related potassium channel 2 (TREK2). It interacts with K2P channel at the negatively charged activator site and modulates channel opening.

BL-1249 is a potassium TREK-1 channel activator.

BL-1249 is a putative activator of potassium TREK-1 channel.

Leistungsmerkmale und Vorteile

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335,H413
• P-Sätze: P273 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves