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B0186

Sigma-Aldrich

BI-6C9

≥97% (HPLC), solid

Synonym(e):

N-[4-[(4-Aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-Butanamide

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About This Item

Empirische Formel (Hill-System):
C23H25N3O4S2
CAS-Nummer:
791835-21-7
Molekulargewicht:
471.59
MDL-Nummer:
MFCD07784498
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24724408
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥97% (HPLC)

Form

solid

Farbe

off-white

Löslichkeit

DMSO: >20 mg/mL

Lagertemp.

−20°C

SMILES String

COc1ccc(cc1)S(=O)(=O)NCCCC(=O)Nc2ccc(Sc3ccc(N)cc3)cc2

InChI

1S/C23H25N3O4S2/c1-30-19-8-14-22(15-9-19)32(28,29)25-16-2-3-23(27)26-18-6-12-21(13-7-18)31-20-10-4-17(24)5-11-20/h4-15,25H,2-3,16,24H2,1H3,(H,26,27)

InChIKey

LCFUJBSKPDPGKO-UHFFFAOYSA-N

Biochem./physiol. Wirkung

BI-6C9 is a tBid inhibitor and antiapoptotic.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
109K4611V
109K46111
109K4611
045K46203
045K46202

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Paolo Armando Gagliardi et al.
The Journal of cell biology, 217(1), 231-249 (2017-11-23)
Extrusion of apoptotic cells from epithelial tissues requires orchestrated morphological rearrangements of the apoptotic cell and its neighbors. However, the connections between the apoptotic cascade and events leading to extrusion are not fully understood. Here, we characterize an apoptotic extrusion
Xinwen Liao et al.
Journal of Cancer, 10(16), 3678-3690 (2019-07-25)
Chaetocin, a natural product extracted from Chaetomium species, possesses anticancer effects in several kinds of tumors. However, it remains unclear whether the potential indication for chaetocin could also include human gastric cancer. We found here that chaetocin induced caspase-dependent and
Lihua Hu et al.
Neurotoxicology, 49, 149-157 (2015-06-27)
Although there are few studies suggested PCP exposure induced developmental and behavioral disorders, however, the occurrence of neurotoxicity and PCP has not been firmly established. Tetrachlorobenzoquinone (TCBQ) is a reactive metabolite of environmental pollutant pentachlorophenol (PCP). To the best of
Sina Oppermann et al.
The Journal of pharmacology and experimental therapeutics, 350(2), 273-289 (2014-05-23)
Mitochondrial demise is a key feature of progressive neuronal death contributing to acute and chronic neurological disorders. Recent studies identified a pivotal role for the BH3-only protein B-cell lymphoma-2 interacting domain death antagonist (Bid) for such mitochondrial damage and delayed
Marieta B Heaton et al.
Alcoholism, clinical and experimental research, 39(1), 55-63 (2015-01-28)
Exposure to ethanol (EtOH) during central nervous system (CNS) development can lead to a wide array of neuroanatomical, behavioral, and cognitive abnormalities, broadly subsumed under the fetal alcohol spectrum disorder classification. One mode of EtOH-induced interference in the normal developmental
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