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A7015

Sigma-Aldrich

N-(2-Fluorenyl)acetamid

≥98% (HPLC)

Synonym(e):

2-Acetamino-fluoren

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About This Item

Empirische Formel (Hill-System):
C15H13NO
CAS-Nummer:
53-96-3
Molekulargewicht:
223.27
Beilstein:
2807677
EG-Nummer:
200-188-6
MDL-Nummer:
MFCD00001116
UNSPSC-Code:
12352103
PubChem Substanz-ID:
24891166
NACRES:
NA.25

Assay

≥98% (HPLC)

Form

powder

mp (Schmelzpunkt)

192-196 °C (lit.)

SMILES String

CC(=O)Nc1ccc-2c(Cc3ccccc-23)c1

InChI

1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17)

InChIKey

CZIHNRWJTSTCEX-UHFFFAOYSA-N

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Anwendung

N-(2-Fluorenyl)acetamide (2-Acetamidofluorene, 2-AAF), a genotoxic carcinogen, is used to induce liver cancer in animal models such as the 2-AAF/partial hepatectomy rat. 2-AAF may be used to study the mechanism of liver carcinogenesis and as a reference material during its identification or quantitation.

Biochem./physiol. Wirkung

A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.

Piktogramme

Health hazardExclamation mark
GHS08,GHS07

Signalwort

Danger

H-Sätze

H302,H350

Gefahreneinstufungen

Acute Tox. 4 Oral - Carc. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Analysenzertifikate (COA)

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Jung-Eun Yeo et al.
Chemical research in toxicology, 25(11), 2462-2468 (2012-10-24)
Nucleotide excision repair (NER) removes lesions caused by environmental mutagens or UV light from DNA. A hallmark of NER is the extraordinarily wide substrate specificity, raising the question of how one set of proteins is able to recognize structurally diverse
Christopher A Traina et al.
Journal of the American Chemical Society, 133(32), 12600-12607 (2011-07-15)
Water-soluble conjugated polymers with controlled molecular weight characteristics, absence of ionic groups, high emission quantum yields, and end groups capable of selective reactions of wide scope are desirable for improving their performance in various applications and, in particular, fluorescent biosensor
Sana Javaid Awan et al.
Cell biology international, 41(1), 51-61 (2016-11-03)
Hepatic oval cells are likely to be activated during advanced stage of liver fibrosis to reconstruct damaged hepatic tissue. However, their scarcity, difficulties in isolation, and in vitro expansion hampered their transplantation in fibrotic liver. This study was aimed to
Ange-Clarisse Dusabineza et al.
Laboratory investigation; a journal of technical methods and pathology, 92(1), 72-81 (2011-09-14)
When hepatocyte proliferation is impaired, liver progenitor cells (LPC) are activated to participate in liver regeneration. We used the 2-acetaminofluorene/partial hepatectomy (AAF/PH) model to evaluate the contribution of LPC to liver cell replacement and function restoration. Fischer rats subjected to
Bu-Gao Zhou et al.
Frontiers in pharmacology, 9, 1165-1165 (2018-11-09)
It is known that excessive hepatocellular apoptosis is a typical characteristic of hepatic disease, and is regulated by the mammalian target of rapamycin (mTOR) signaling pathway. As the main active component of Kudzu (Pueraria lobata) roots, which is frequently used
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DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Carcinogenesis and Epigenetics

Carcinogenesis and Epigenetics

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