A6816

(±)-AMPA

solid

• Synonym(e): (±)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrate
• Empirische Formel (Hill-System): C₇H₁₀N₂O₄
• Molekulargewicht: 186.17
• MDL-Nummer: MFCD00213388
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24891141
• NACRES: NA.32

Eigenschaften

• Form: solid
• Farbe: white
• Löslichkeit: H₂O: 1 mg/mL (warm); 0.1 M HCl: 3.5 mg/mL; 0.1 M NaOH: 4.3 mg/mL; DMSO: 4.3 mg/mL; 1 M HCl: 50 mg/mL
• SMILES String: O.Cc1onc(O)c1CC(N)C(O)=O
• InChI: 1S/C7H10N2O4.H2O/c1-3-4(6(10)9-13-3)2-5(8)7(11)12;/h5H,2,8H2,1H3,(H,9,10)(H,11,12);1H2
• InChIKey: HFISYNCCKQHIAM-UHFFFAOYSA-N
• Angaben zum Gen: rat ... Gria1(50592) , Gria2(29627) , Gria3(29628) , Gria4(29629) , Grik1(29559) , Grik2(54257) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm4(24417) , Grm5(24418) , Slc1a1(25550) , Slc1a2(29482) , Slc1a3(29483)

Beschreibung

Anwendung

(±)-AMPA has been used:

• in vivo

• whole-cell patch-clamp recording in Müller glial cells
• to test its excitotoxic effects in hippocampal slice cultures
• in retinal horizontal cells (HCs) culture to test its effect on Ca²⁺ signals

Biochem./physiol. Wirkung

Potent excitatory amino acid that interacts selectively with central AMPA/kainate receptors.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)