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Merck

A3234

Sigma-Aldrich

Apolipoprotein E4 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE and HPLC), lyophilized powder

Synonym(e):

ApoE4

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About This Item

MDL-Nummer:
UNSPSC-Code:
12352202
NACRES:
NA.32

Rekombinant

expressed in E. coli

Qualitätsniveau

Assay

≥90% (SDS-PAGE and HPLC)

Form

lyophilized powder

UniProt-Hinterlegungsnummer

Lagertemp.

−20°C

Angaben zum Gen

human ... APOE(348)

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Allgemeine Beschreibung

Apolipoprotein E (ApoE) is present in the brain and is mainly produced by astrocytes. It is a 299 amino acid glycoprotein of 34kDa. It is present in all classes of lipoproteins except LDL (low-density lipoprotein). APOE gene has three alleles, such as APOE ε3, APOE ε4 and APOE ε2. It is located on human chromosome 19q13.

Biochem./physiol. Wirkung

ApoE4 (apolipoprotein E4) is associated with AD (Alzheimer′s disease).
Apolipoprotein E4 is a member of the apolipoprotein E family of plasma lipoproteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. ApoE4 regulates plasma lipid levels by increasing the degradation of particles rich in triglycerides and cholesterol. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, regulate the activity of enzymes involved in lipid metabolism and bind amyloid-β protein, the major component of plaques in Alzheimer′s disease, which it delivers to the microglia, the major scavenger cells of brain. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer′s disease. ApoE exists in three major isoforms: E2, E3, and E4, which differ from one another by a single amino-acid substitution. Recombinant human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.

Physikalische Form

Lyophillized from a 0.2 μm filtered solution in 20 mM sodium phosphate, pH 7.8.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models
Huang Y
Biochemical Society Transactions, 120(4), 702-736 (2011)
Twenty years of the Alzheimer?s disease amyloid hypothesis: a genetic perspective
Tanzi R E and Bertram L
Cell, 120(4), 545-555 (2005)
Lipids and disorders of lipoprotein metabolism
Clinical Biochemistry, 120(4), 702-736 (2014)
Traumatic Brain Injury
Neurobiology of Brain Disorders, 120(4), 219-235 (2015)

Artikel

Alzheimer's disease (AD) is the most common cause of dementia in the elderly and is characterized by gradual loss of cognitive functions.

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