70485

Naphthol-AS-E-Phosphat

suitable for histology

• Synonym(e): KG-501
• Empirische Formel (Hill-System): C₁₇H₁₃ClNO₅P
• CAS-Nummer: 18228-17-6
• Molekulargewicht: 377.72
• Beilstein: 6664478
• EG-Nummer: 242-106-1
• MDL-Nummer: MFCD00042718
• UNSPSC-Code: 12352204
• PubChem Substanz-ID: 329762485
• NACRES: NA.83

Eigenschaften

• Assay: ≥80% (HPLC)
• Qualitätsniveau: 100
• Form: powder
• Anwendung(en): histology
• Lagertemp.: 2-8°C
• SMILES String: OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3
• InChI: 1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
• InChIKey: RQAQWBFHPMSXKR-UHFFFAOYSA-N

Beschreibung

Anwendung

Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis that oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).

Biochem./physiol. Wirkung

Naphthol AS-E phosphate/KG501, a small-molecule antagonist has the ability to prevent cAMP-response element-binding protein (CREB) pathway. It can also interfere with the interaction of Myb-KIX in vitro and block the actions of Myb in vivo.

Sonstige Hinweise

Histochemical substrate for alkaline phosphatases,KG-501 blocks cAMP-induction of CREB (cAMP Response Element Binding Protein)-dependent target gene transcription (Ki 10 microM)) through interference in the binding between the KID domain of CREB and KIX domain of CBP (CREB Binding Protein), classic activator-coactivator interaction.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)