SMB00929

5′-Hydroxy carvedilol

≥95% (HPLC)

• Synonym(e): 5′-Hydroxy carvedilol, 3-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-4-methoxyphenol, 5′-Hydroxyphenyl carvedilol, 5′-Hydroxyphenylcarvedilol, 5′-OH carvedilol, 5-Hydroxycarvedilol, 5OHC, BM-140830, Carvedilol metabolite M5
• Empirische Formel (Hill-System): C₂₄H₂₆N₂O₅
• CAS-Nummer: 142227-51-8
• Molekulargewicht: 422.47
• UNSPSC-Code: 12352200
• NACRES: NA.25

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: solid
• Farbe: off-white
• Löslichkeit: DMSO: soluble, clear, colorless
• Lagertemp.: 2-8°C
• InChI: 1S/C24H26N2O5/c1-29-21-10-9-16(27)13-23(21)30-12-11-25-14-17(28)15-31-22-8-4-7-20-24(22)18-5-2-3-6-19(18)26-20/h2-10,13,17,25-28H,11-12,14-15H2,1H3
• InChIKey: PVUVZUBTCLBJMT-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Carvedilol is a β- and α1-adrenoreceptor blocker for the treatment of hypertension and congestive heart failure (CHF). The drug is metabolized by CYP2D6 (to 4′-OH and 5′-OH), CYP2C9 (to O-desmethyl), CYP1A2 (to 8-OH). It is also oxidized to 1-OH carvedilol, but the enzyme involved is not yet clear. These metabolites are useful markers for studying and monitoring the activities of cytochrome metabolizing enzymes. M4 metabolite (4′-OH), but not M2 or M5, is most likely to contribute to total β-adrenoceptor blocking activity due to its higher potency.

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Sicherheitshinweise

• Piktogramme: GHS08,GHS09
• Signalwort: Warning
• H-Sätze: H373,H411
• P-Sätze: P260 - P273 - P314 - P391 - P501
• Gefahreneinstufungen: Aquatic Chronic 2 - STOT RE 2
• Zielorgane: Liver,spleen,Adrenal gland,Uterus (including cervix)
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable