PHR1787

Cytarabin

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): Cytosin β-D-Arabinofuranosid, (β-D-Arabinofuranosyl)-cytosin, Ara-C, Arabinocytidin, Arabinosylcytosin, Cytarabin, Cytosinarabinosid
• Empirische Formel (Hill-System): C₉H₁₃N₃O₅
• CAS-Nummer: 147-94-4
• Molekulargewicht: 243.22
• Beilstein: 89175
• EG-Nummer: 205-705-9
• MDL-Nummer: MFCD00066487
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329823613
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; pharmaceutical secondary standard
• Qualitätsniveau: 300
• Agentur: traceable to BP 383; traceable to Ph. Eur. C3350000; traceable to USP 1162002
• API-Familie: cytarabine
• Analysenzertifikat (CofA): current certificate can be downloaded
• Verpackung: pkg of 500 mg
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-8°C
• SMILES String: NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
• InChI: 1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
• InChIKey: UHDGCWIWMRVCDJ-CCXZUQQUSA-N
• Angaben zum Gen: human ... POLA1(5422) , POLA2(23649) , POLD1(5424) , POLD2(5425) , POLD3(10714) , POLD4(57804) , POLE(5426) , POLE2(5427) , POLE3(54107) , PRIM1(5557) , PRIM2(5558)

Beschreibung

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Anwendung

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Ara-C wird in DNA eingebaut und hemmt die DNA-Replikation durch Bildung von Spaltkomplexen mit Topoisomerase I, was zu einer Fragmentierung der DNA führt; die RNA-Synthese wird nicht gehemmt. Anti-Leukämiemittel.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

Dieses Produkt wurde für Genauigkeit und Stabilität gemäss den Normen ISO / IEC 17025:2005, (AClass Cert AT-1467) und ISO GUIDES 34:2009 (AClass Cert AR-1470) produziert und geprüft.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAB3688 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H317,H361fd
• P-Sätze: P202 - P261 - P272 - P280 - P302 + P352 - P308 + P313
• Gefahreneinstufungen: Repr. 2 - Skin Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3