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Merck

46738

Supelco

Spectinomycin -dihydrochlorid Pentahydrat

VETRANAL®, analytical standard

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About This Item

Empirische Formel (Hill-System):
C14H24N2O7 · 2HCl · 5H2O
CAS-Nummer:
Molekulargewicht:
495.35
Beilstein:
5684150
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
41116107
PubChem Substanz-ID:
NACRES:
NA.24

Qualität

analytical standard

Qualitätsniveau

Produktlinie

VETRANAL®

Haltbarkeit

limited shelf life, expiry date on the label

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Löslichkeit

H2O: soluble at 

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria

Anwendung(en)

clinical testing

Format

neat

Wirkungsweise

protein synthesis | interferes

Lagertemp.

2-8°C

SMILES String

Cl[H].Cl[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H][C@@]12O[C@H](C)CC(=O)[C@]1(O)O[C@]3([H])[C@@H](NC)[C@@H](O)[C@@H](NC)[C@H](O)[C@@]3([H])O2

InChI

1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1

InChIKey

DCHJOVNPPSBWHK-UXXUFHFZSA-N

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Allgemeine Beschreibung

Chemical structure: aminoglycoside

Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Spectinomycin dihydrochloride pentahydrate may be used as a reference standard for the determination of spectinomycin in bovine milk samples by liquid chromatography with electrochemical detection.
Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.

Vorsicht

Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.

Angaben zur Herstellung

Stock solutions should be prepared at 10 mg/mL in water and filter sterilized.

Rechtliche Hinweise

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Piktogramme

Exclamation mark

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Determination of spectinomycin residues in bovine milk using liquid chromatography with electrochemical detection.
Schermerhorn PG, et al.
Journal of Agricultural and Food Chemistry, 43(8), 2122-2125 (1995)
Gaylen A Uhlich et al.
Plasmid, 67(3), 259-263 (2011-12-27)
A novel cloning vector to aid in the construction of single copy β-galactosidase reporter systems for gene expression studies in lactose metabolizing Escherichia coli strains, including STEC, is described. The plasmid allows construction of translational fusions of cloned gene promoters
Jiefeng Zhang et al.
The Science of the total environment, 445-446, 281-298 (2013-01-23)
Cytostatic drugs have been widely used for chemotherapy for decades. However, many of them have been categorized as carcinogenic, mutagenic and teratogenic compounds, triggering widespread concerns about their occupational exposure and ecotoxicological risks to the environment. This review focuses on
Brigitta Dudas et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 125(7), 1517-1523 (2012-07-14)
We report here the isolation of spectinomycin-resistant mutants in cultured cells of Medicago sativa line RegenSY-T2. Spectinomycin induces bleaching of cultured alfalfa cells due to inhibition of protein synthesis on the prokaryotic type 70S plastid ribosomes. Spontaneous mutants resistant to
Yi-Ywan M Chen et al.
Applied and environmental microbiology, 77(12), 3967-3974 (2011-05-03)
Streptococcus parasanguinis is among the most successful colonizers of the human body. Strain FW213 harbors a 7.0-kb cryptic plasmid, pFW213, with a copy number at 5 to 10 per chromosome. Sequence and functional analyses of pFW213 revealed that the open

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