14400

Biotin

≥99.0% (T)

• Synonym(e): D-Biotin, Bios II, Coenzym R, Vitamin B7, Vitamin H
• Empirische Formel (Hill-System): C₁₀H₁₆N₂O₃S
• CAS-Nummer: 58-85-5
• Molekulargewicht: 244.31
• Beilstein: 86838
• EG-Nummer: 200-399-3
• MDL-Nummer: MFCD00005541
• UNSPSC-Code: 12352201
• eCl@ss: 34058011
• PubChem Substanz-ID: 329750287
• NACRES: NA.21

Eigenschaften

• Biologische Quelle: synthetic
• Qualitätsniveau: 200
• Assay: ≥99.0% (T)
• Form: powder
• Optische Aktivität: [α]20/D +91±2°, c = 1% in 0.1 M NaOH
• Glührückstand: ≤0.1% (as SO₄)
• Verlust: ≤0.5% loss on drying
• Farbe: colorless to white
• mp (Schmelzpunkt): 229-234 °C; 231-233 °C (lit.)
• Löslichkeit: alcohol: soluble 80mg/100 ml at 25 °C; water: soluble 22mg/100 ml at 25 °C; 0.1 M NaOH: 10 mg/mL at 25 °C, clear, colorless; H₂O: very soluble; organic solvents: insoluble
• Kationenspuren: Ca: ≤50 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤10 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤500 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• Anwendung(en): detection
• SMILES String: [H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2
• InChI: 1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
• InChIKey: YBJHBAHKTGYVGT-ZKWXMUAHSA-N

Beschreibung

Allgemeine Beschreibung

Biotin is readily available in several foods, like whole grains, nuts, legumes, unpolished rice and egg yolk. The normal gut flora also produces this vitamin.

Anwendung

Biotin has been used for testing the functionality of the Avidin-displaying phages. The product has also been used for labeling the swine anti-rabbit IgG antibody and peroxidase.

Biochem./physiol. Wirkung

Biotin acts as an important cofactor for carboxylase enzymes in various metabolic pathways. Biotin favors keratin synthesis and hence is used as a supplement for hair and nail growth. Deficiency of biotin shows several symptoms such as alopecia, conjunctivitis, seborrheic dermatitis, depression, lethargy, hypotonia and seizures.

Biotin also referred to as vitamin H or vitamin B7 is a water-soluble B-vitamin that induces two to three fold increase in guanylate cyclase activity in rat liver, kidney, colon, cerebellum, and heart. It also stimulates the sperm motility and prolongs the survival of cryopreserved human spermatozoa.

Sonstige Hinweise

Reviews; Avidin-Biotin technology;

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)