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Key Documents

MABX1901

Sigma-Aldrich

Anti-human IgG (1mg) KC

from mouse

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Antikörperform

purified antibody

Antikörper-Produkttyp

secondary antibodies

Klon

monoclonal

Speziesreaktivität

human

Methode(n)

ELISA: suitable
immunodiffusion: suitable

Isotyp

IgG2b

Verwandte Kategorien

Allgemeine Beschreibung

Secondary antibody specific for Human Immunoglobulin G
Immunoglobulin G (IgG), an immunoglobulin isotype, is the most abundant protein in human serum and constitutes 10-20% of plasma protein. It is composed of glycoproteins comprising 82-96% of proteins and 4-18% of carbohydrates. IgG is further classified into IgG1, IgG2, IgG3, and IgG4 subclasses. IgG consists of four polypeptide chains, with two heavy chains (γ chains) and two light chains (κ or λ chains), which are linked by inter-chain disulfide bonds. It is secreted by B lymphocytes and found in extracellular fluids and blood.

Spezifität

Specific for Human IgG. No cross reactivity with human IgA, IgD, IgE or IgE.

Immunogen

corresponding to Human Serum IgG.

Anwendung

Detect Human Serum IgG using this mouse monoclonal Anti-human IgG (1mg) KC, Cat. No. MABX1901-1KC, validated for use in Lateral Flow Assay and ELISA.

Biochem./physiol. Wirkung

Immunoglobulin G (IgG) primarily contributes to the humoral immune response by neutralizing pathogens such as bacteria, viruses, and protect cells from their toxic substances. IgG is the only isotype transferred to the fetus across the placenta and is vital for immune response of the neonate. Alterations in IgG fragment crystallizable (Fc)-glycosylation are associated with various diseases including rheumatoid arthritis and tuberculosis.

Qualität

Tested

Physikalische Form

Format: Purified

Sonstige Hinweise

Concentration: Please refer to lot specific datasheet.

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Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

The N-glycosylation of mouse immunoglobulin G (IgG)-fragment crystallizable differs between IgG subclasses and strains.
de Haan N, et al.
Frontiers in immunology, 8, 608-608 (2017)
Placental transfer of IgG subclasses in a Japanese population.
Hashira S, et al.
Pediatrics International, 42(4) (2000)
Gestur Vidarsson et al.
Frontiers in immunology, 5, 520-520 (2014-11-05)
Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These

Artikel

Antibody-based serology tests are useful in identifying subjects with an adaptive immune response to the SARS-CoV-2 virus. Anti-human immunoglobulin antibodies allow for quick and simple, yet reliable assays with easy readouts and can also be adapted for high-throughput screening.

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

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