MABS441

Anti-WBP2 Antibody, clone 4C8H10

clone 4C8H10, from mouse

• Synonym(e): WW domain-binding protein 2, WBP-2
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 4C8H10, monoclonal
• Speziesreaktivität: human
• Methode(n): immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• Isotyp: IgG1κ
• NCBI-Hinterlegungsnummer: NP_036610
• UniProt-Hinterlegungsnummer: Q969T9
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... WBP2(23558)

Beschreibung

Allgemeine Beschreibung

WBP2 is a protein-protein interacting protein that binds to the WW domain of YAP1, WWP1 and WWP2 proteins. WW domain-containing proteins are found in most cells and play important roles in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. They are also upregulated in many cancers. WBP2 also interacts with the ubiquitin ligase proteins belonging to the NEDD4 family and appears to assist in the regulation of targeting proteins to proteasomes or lysosomes. Also in WBP2 knockout mice, the mice display abnormal brainstem and hearing development, indicating an important role in development as well.

Immunogen

GST-tagged full length recombinant protein corresponding to Human WBP2.

Anwendung

Research Category
Zelluläre Signaltransduktion

Apoptose & Krebs

Research Sub Category
Wachstumsfaktoren & -rezeptoren

Immunohistochemistry Analysis: A representative lot detected WBP2 in breast cancer tissue at 1.25 ug/ml
Immunocytochemistry Analysis: A representative lot detected WBP2 in transfected HeLa cell fixed with 4% paraformaldehyde at 20 ug/ml
Immunoprecipitation Analysis: A representative lot immunoprecipitated transfected V5-WBP2 from HeLa cell

This Anti-WBP2 Antibody, clone 4C8H10 is validated for use in Western Blotting and Immunoprecipitation and Immunocytochemistry and Immunohistochemistry for the detection of WBP2.

Qualität

Evaluated by Western Blotting in MDA-MB-231 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected WBP2 in 10 µg of MDA-MB-231 cell lysate.

Zielbeschreibung

~ 37 kDa observed

Physikalische Form

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Sonstige Hinweise

Concentration: Please refer to lot specific datasheet.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable